ChemicalBook > CAS DataBase List > ONO-8590580

ONO-8590580

Product Name: ONO-8590580
CAS No.: 1802661-73-9
Chemical Name: ONO-8590580
Synonyms: CS-2894;ONO-8590580;ONO-8590580, 10 mM in DMSO;ONO-8590580;ONO 8590580;ONO8590580;1-(Cyclopropylmethyl)-5-fluoro-4-methyl-N-[5-(1-methyl-1H-imidazol-4-yl)-2-pyridinyl]-1H-benzimidazol-6-amine;1H-Benzimidazol-6-amine, 1-(cyclopropylmethyl)-5-fluoro-4-methyl-N-[5-(1-methyl-1H-imidazol-4-yl)-2-pyridinyl]-;1-(cyclopropylmethyl)-5-fluoro-4-methyl-N-[5-(1-methyl-1H-imidazol-4-yl)pyridin-2-yl]-1H-1,3-benzodiazol-6-amine;γ-Aminobutyric acid Receptor,ONO8590580,Inhibitor,Gamma-aminobutyric acid Receptor,ONO-8590580,inhibit,GABA Receptor,ONO 8590580
CBNumber: CB74662621
Molecular Formula: C21H21FN6
Formula Weight: 376.43
MOL File: 1802661-73-9.mol

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ONO-8590580 Property

Boiling point:: 610.4±65.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A crystalline solid
pka: 4.95±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0064395
Product name: ONO-8590580
Purity: 99.85%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0064395
Product name: ONO-8590580
Purity: 99.85%
Packaging: 10mg
Price: $390
Updated: 2021/12/16

ChemScene

Product number: CS-0064395
Product name: ONO-8590580
Purity: 99.85%
Packaging: 25mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0064395
Product name: ONO-8590580
Purity: 99.85%
Packaging: 50mg
Price: $1350
Updated: 2021/12/16

ChemScene

Product number: CS-0064395
Product name: ONO-8590580
Purity: 99.85%
Packaging: 100mg
Price: $1950
Updated: 2021/12/16

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ONO-8590580 Chemical Properties,Usage,Production

Uses

ONO-8590580 is a GABAA α5 negative allosteric modulator.

in vivo

The effect of ONO-8590580 on the MK-801/scopolamine-induced cognitive deficit in the 8-arm radial maze test is investigated. Doses of MK-801 and scopolamine for this test are 0.075 mg/kg (i.p.) and 0.2 mg/kg (i.p.) respectively. ONO-8590580 (20 mg/kg, p.o.) significantly decreases the number of errors and total latency compared to the control. The present study in which ONO-8590580 but not donepezil significantly decreases the number of errors may suggest that ONO-8590580 could be more potent for the treatment of AD patients. The data showing that ONO-8590580 has not anxiogenic-like or proconvulsant effects are in agreement with the behavioral phenotype of α5-/- mice^[1].

References

[1] Kawaharada S, et al. ONO-8590580, a Novel GABAAα5 Negative Allosteric Modulator Enhances Long-Term Potentiation and Improves Cognitive Deficits in Preclinical Models. J Pharmacol Exp Ther. 2018 Jul;366(1):58-65. DOI:10.1124/jpet.117.247627

ONO-8590580 Preparation Products And Raw materials

Raw materials

Preparation Products

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1802661-73-9, ONO-8590580Related Search:

ONO-8590580

1H-Benzimidazol-6-amine, 1-(cyclopropylmethyl)-5-fluoro-4-methyl-N-[5-(1-methyl-1H-imidazol-4-yl)-2-pyridinyl]-

1-(cyclopropylmethyl)-5-fluoro-4-methyl-N-[5-(1-methyl-1H-imidazol-4-yl)pyridin-2-yl]-1H-1,3-benzodiazol-6-amine

CS-2894

ONO-8590580;ONO 8590580;ONO8590580

1-(Cyclopropylmethyl)-5-fluoro-4-methyl-N-[5-(1-methyl-1H-imidazol-4-yl)-2-pyridinyl]-1H-benzimidazol-6-amine

γ-Aminobutyric acid Receptor,ONO8590580,Inhibitor,Gamma-aminobutyric acid Receptor,ONO-8590580,inhibit,GABA Receptor,ONO 8590580

ONO-8590580, 10 mM in DMSO

1802661-73-9

C21H21FN6