KLH45
- Product Name
- KLH45
- CAS No.
- 1632236-44-2
- Chemical Name
- KLH45
- Synonyms
- KLH45;KLH45 >=98% (HPLC);N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide;2H-1,2,3-Triazole-2-carboxamide, N-cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-
- CBNumber
- CB74666104
- Molecular Formula
- C24H25F3N4O2
- Formula Weight
- 458.48
- MOL File
- 1632236-44-2.mol
KLH45 Property
- Boiling point:
- 561.0±60.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- solubility
- DMSO:30.0(Max Conc. mg/mL);65.43(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);65.43(Max Conc. mM) - pka
- -1.76±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 19889
- Product name
- KLH45
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19889
- Product name
- KLH45
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 19889
- Product name
- KLH45
- Packaging
- 10mg
- Price
- $178
- Updated
- 2024/03/01
- Product number
- 19889
- Product name
- KLH45
- Packaging
- 25mg
- Price
- $365
- Updated
- 2024/03/01
- Product number
- 5865
- Product name
- KLH45
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $168
- Updated
- 2021/12/16
KLH45 Chemical Properties,Usage,Production
Description
KLH45 is an inhibitor of the phospholipase DDHD domain containing 2 (DDHD2; IC50 = 1.3 nM). It is selective for DDHD2 over greater than 50 serine hydrolases, including DDHD1 and Sec23ip, but does inhibit α/β-hydrolase domain-containing protein 6 (ABHD6). It inhibits DDHD2 and ABHD6 in Neuro2A cells when used at a concentration of less than 10 nM and inhibits DDHD2 by greater than 95% at a concentration of 25 nM. KLH45 (2 μM) prevents increases in triacylglycerol (TAG) hydrolase activity in HEK293T cell lysates expressing recombinant DDHD2 and incubated with a radiolabeled TAG substrate. It decreases TAG levels in the CNS of mice when administered at a dose of 20 mg/kg twice per day for four days. KLH45 (2 μM) also reverses DDHD2-induced lipid droplet reduction in COS-7 cells expressing recombinant DDHD2 and loaded with oleic acid.
Uses
KLH45 is a novel selective inhibitor of DDHD2.
KLH45 Preparation Products And Raw materials
Raw materials
Preparation Products
KLH45 Suppliers
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