KLH45

Product Name: KLH45
CAS No.: 1632236-44-2
Chemical Name: KLH45
Synonyms: KLH45;KLH45 >=98% (HPLC);N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide;2H-1,2,3-Triazole-2-carboxamide, N-cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-
CBNumber: CB74666104
Molecular Formula: C24H25F3N4O2
Formula Weight: 458.48
MOL File: 1632236-44-2.mol

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KLH45 Property

Boiling point:: 561.0±60.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
solubility: DMSO:30.0(Max Conc. mg/mL);65.43(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);65.43(Max Conc. mM)
form: Solid-Liquid Mixture
pka: -1.76±0.20(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19889
Product name: KLH45
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19889
Product name: KLH45
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 19889
Product name: KLH45
Packaging: 10mg
Price: $178
Updated: 2024/03/01

Cayman Chemical

Product number: 19889
Product name: KLH45
Packaging: 25mg
Price: $365
Updated: 2024/03/01

Tocris

Product number: 5865
Product name: KLH45
Purity: ≥98%(HPLC)
Packaging: 10
Price: $168
Updated: 2021/12/16

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KLH45 Chemical Properties,Usage,Production

Description

KLH45 is an inhibitor of the phospholipase DDHD domain containing 2 (DDHD2; IC₅₀ = 1.3 nM). It is selective for DDHD2 over greater than 50 serine hydrolases, including DDHD1 and Sec23ip, but does inhibit α/β-hydrolase domain-containing protein 6 (ABHD6). It inhibits DDHD2 and ABHD6 in Neuro2A cells when used at a concentration of less than 10 nM and inhibits DDHD2 by greater than 95% at a concentration of 25 nM. KLH45 (2 μM) prevents increases in triacylglycerol (TAG) hydrolase activity in HEK293T cell lysates expressing recombinant DDHD2 and incubated with a radiolabeled TAG substrate. It decreases TAG levels in the CNS of mice when administered at a dose of 20 mg/kg twice per day for four days. KLH45 (2 μM) also reverses DDHD2-induced lipid droplet reduction in COS-7 cells expressing recombinant DDHD2 and loaded with oleic acid.

Uses

KLH45 is a novel selective inhibitor of DDHD2.

KLH45 Preparation Products And Raw materials

Raw materials

Preparation Products

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KLH45 Suppliers

China 32 United Kingdom 1 United States 6 Global 39

BOC Sciences

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Shanghai Lollane Biological Technology Co.,Ltd.

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ShangHai Biochempartner Co.,Ltd

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Shanghai Hongye Biotechnology Co. Ltd

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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
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DC Chemicals

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Changzhou Chenhong Biotechnology Co., Ltd.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

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1632236-44-2, KLH45Related Search:

KLH45

N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide

KLH45 >=98% (HPLC)

2H-1,2,3-Triazole-2-carboxamide, N-cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-

1632236-44-2