Calcitonin (salmon) (trifluoroacetate salt)
- Product Name
- Calcitonin (salmon) (trifluoroacetate salt)
- CAS No.
- 171052-37-2
- Chemical Name
- Calcitonin (salmon) (trifluoroacetate salt)
- Synonyms
- Calcitonin (salmon) (trifluoroacetate salt);L-cysteinyl-L-seryl-L-asparaginyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucylglycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-α-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-Lthreonyl-L-asparaginyl-L-threonylglycyl-L-serylglycyl-L-threonyl-L-prolinamide,cyclic(1→7)-disulfide,trifluoroacetatesalt
- CBNumber
- CB74666346
- Molecular Formula
- C147H241F3N44O50S2
- Formula Weight
- 3545.92
- MOL File
- 171052-37-2.mol
Calcitonin (salmon) (trifluoroacetate salt) Property
- storage temp.
- Store at -20°C
- solubility
- Water: 1 mg/ml
- form
- A lyophilized powder
N-Bromosuccinimide Price
- Product number
- 24410
- Product name
- Calcitonin (salmon) (trifluoroacetate salt)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $130
- Updated
- 2024/03/01
Calcitonin (salmon) (trifluoroacetate salt) Chemical Properties,Usage,Production
Description
Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption.1,2 It belongs to the calcitonin family of peptides, which also includes amylin , calcitonin gene-related peptide , and adrenomedullin.3 The binding of salmon calcitonin to the human calcitonin receptor (CTR) is not modulated by receptor activity-modifying proteins (RAMPs), which influence affinity of human calcitonin to CTR.4,5 Salmon calcitonin binds to human CTR2 with IC50 values of 0.933, 0.224, 0.134, and 0.317 nM alone and with RAMP1, 2, or 3, respectively. It induces cAMP accumulation in COS-7 cells transfected with CTR2 (EC50 = 0.166 nM).6 Salmon calcitonin inhibits bone resorption by osteoclasts in a pit formation assay using rat bone slices (ID50 = 0.003 pg/mL) and lowers calcium level in vivo in a bioassay of hypocalcemia in rats (ED15 = 33.9 mg/kg).7 Formulations containing salmon calcitonin have been used to treat hypercalcemia, bone destruction by osteoporosis, and Paget's disease.2
References
1. Foster, G.V. Calcitonin. A review of experimental and clinical investigations Postgrad. Med. J. 44(511),411-422(1968).
2. Chesnut, C.H., III, Azria, M., Silverman, S., et al. Salmon calcitonin: A review of current and future therapeutic indications Osteoporos. Int. 19(4),479-491(2008).
3. Wimalawansa, S.J. Amylin, calcitonin gene-
4. Muff, R., Bühlmann, N., Fischer, J.A., et al. An amylin receptor is revealed following co-
5. Christopoulos, G., Perry, K.J., Morfis, M., et al. Multiple amylin receptors arise from receptor activity-
6. Udawela, M., Christopoulos, G., Tilakaratne, N., et al. Distinct receptor activity-
7. McSheehy, P.M., Farina, C., Airaghi, R., et al. Pharmacologic evaluation of the calcitonin analogue SB 205614 in models of osteoclastic bone resorption in vitro and in vivo: Comparison with salmon calcitonin and elcatonin Bone 16(4),435-444(1995).
Calcitonin (salmon) (trifluoroacetate salt) Preparation Products And Raw materials
Raw materials
Preparation Products
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