N-Acetylpuromycin

Product Name: N-Acetylpuromycin
CAS No.: 22852-13-7
Chemical Name: N-Acetylpuromycin
Synonyms: N-Acetylpuromycin;3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine;Adenosine, 3'-[[(2S)-2-(acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-
CBNumber: CB74666508
Molecular Formula: C24H31N7O6
Formula Weight: 513.55
MOL File: 22852-13-7.mol

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N-Acetylpuromycin Property

Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 70 mg/ml) or in DMF (up to 55 mg/ml)
form: solid
pka: 12.98±0.70(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 2 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25335
Product name: N-Acetylpuromycin
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 25335
Product name: N-Acetylpuromycin
Purity: ≥98%
Packaging: 5mg
Price: $134
Updated: 2024/03/01

Cayman Chemical

Product number: 25335
Product name: N-Acetylpuromycin
Purity: ≥98%
Packaging: 10mg
Price: $213
Updated: 2024/03/01

Cayman Chemical

Product number: 25335
Product name: N-Acetylpuromycin
Purity: ≥98%
Packaging: 25mg
Price: $442
Updated: 2024/03/01

Tocris

Product number: 5679
Product name: N-Acetylpuromycin
Purity: ≥98%(HPLC)
Packaging: 10
Price: $195
Updated: 2021/12/16

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N-Acetylpuromycin Chemical Properties,Usage,Production

Description

N-Acetylpuromycin is a non-ribotoxic form of the antibiotic puromycin that is formed in puromycin-resistant S. alboniger that endogenously express puromycin-acetyltransferase. In AD293(Pr) cells that express puromycin-N-acetyltransferase, the enzyme responsible for the biosynthesis of N-acetylpuromycin, puromycin application induces downregulation of the negative regulators of TGF-β signalling SnoN and Ski without activating MAPK or inhibition of protein synthesis.

Uses

N-Acetylpurinomycin downregulates SnoN and Ski protein expression and promotes TGF-β signaling, independently of MAPK activation.

storage

Store at -20°C

References

1) Hernandez-Damian?et al. (2013),?Downregulation of SnoN oncoprotein induced by antibiotics anisomycin and puromycin positively regulates transforming growth factor-β signals; Biochim. Biophys. Acta,?1830?5049

N-Acetylpuromycin Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Acetylpuromycin Suppliers

China 8 United Kingdom 1 United States 5 Global 14

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Beijing Biocreative Technology Co., Ltd.

Tel: 15522676233
Email: 3007606172@qq.com
Country: China
ProdList: 1248
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24641
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11974
Advantage: 58

Hubei Danding Pharmaceutical Technology Co., Ltd

Tel: 17701422016
Email: 181646821@qq.com
Country: China
ProdList: 9314
Advantage: 58

R&D Systems, Inc

Tel: 18003437475 18003437475
Fax: 1-612-656-4400
Email: rdname@qq.com
Country: China
ProdList: 35733
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

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N-Acetylpuromycin

3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine

Adenosine, 3'-[[(2S)-2-(acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-

22852-13-7

C24H31N7O6