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Octreotide (acetate)

Product Name
Octreotide (acetate)
CAS No.
760176-26-9
Chemical Name
Octreotide (acetate)
CBNumber
CB74666735
Molecular Formula
C51H70N10O12S2
Formula Weight
1079.3
MOL File
760176-26-9.mol
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Octreotide (acetate) Property

solubility 
DMSO: Slightly Soluble; Methanol: Slightly Soluble; Water: 1 mg/ml
form 
A solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23757
Product name
Octreotide (acetate)
Purity
≥95%
Packaging
1mg
Price
$31
Updated
2023/06/20
Cayman Chemical
Product number
23757
Product name
Octreotide (acetate)
Purity
≥95%
Packaging
5mg
Price
$136
Updated
2023/06/20
Cayman Chemical
Product number
23757
Product name
Octreotide (acetate)
Purity
≥95%
Packaging
10mg
Price
$238
Updated
2023/06/20
Cayman Chemical
Product number
23757
Product name
Octreotide (acetate)
Purity
≥95%
Packaging
25mg
Price
$559
Updated
2023/06/20
AK Scientific
Product number
9422EN
Product name
Aceticacid;(7R,10R,19S)-10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Packaging
25mg
Price
$733
Updated
2021/12/16
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Octreotide (acetate) Chemical Properties,Usage,Production

Description

Octreotide is an octapeptide analog of somatostatin that binds to somatostatin receptors (SSTRs) with a higher affinity for the somatostatin subgroup 2 receptors, SST2, SST3, and SST5 (Kis = 875, 0.57, 26.8, >1,000, and 6.8 nM for SST1-5 receptors, respectively).1 Within subgroup 2 SSTRs, it selectively binds to SST2 over SST3 and SST5 receptors with IC50 values of 0.02, 92.9, and 21.8 nM, respectively, for human receptors. Octreotide inhibits the secretion of growth hormone in vitro in rat pituitary cells three-fold more potently than somatostatin and in vivo in rhesus monkey (ID50 = 0.38 μg/kg per hour).2 It inhibits proliferation of VEGF-stimulated human umbilical endothelial cells (HUVECs) with an EC50 value of approximately 1 μM.3 It also inhibits growth of LCI-D20 human hepatocellular carcinoma cell tumors in a nude mouse xenograft model when administered at a dose of 50 μg/kg twice daily. Formulations containing octreotide have been used in the treatment of acromegaly to reduce growth hormone and IGF-1 levels.

References

1. Moore, S.B., van der Hoek, J., de Capua, A., et al. Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from rat pituitary cells J. Med. Chem. 48(21),6643-6652(2005).
2. Bauer, W., Briner, U., Doepfner, W., et al. SMS 201-995: A very potent and selective octapeptide analogue of somatostatin with prolonged action Life Sci. 31(11),1133-1140(1982).
3. Jia, W.-D., Xu, G.-L., Xu, R.-N., et al. Octreotide acts as an antitumor angiogenesis compound and suppresses tumor growth in nude mice bearing human hepatocellular carcinoma xenografts J. Cancer Res. Clin. Oncol. 129(6),327-334(2003).

Octreotide (acetate) Preparation Products And Raw materials

Raw materials

Preparation Products

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Octreotide (acetate) Suppliers

China 3 United States 2 Global 5
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11974
Advantage
58
Hubei Danding Pharmaceutical Technology Co., Ltd
Tel
17701422016
Email
181646821@qq.com
Country
China
ProdList
9314
Advantage
58

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