BGC 20-1531 (hydrochloride)
- Product Name
- BGC 20-1531 (hydrochloride)
- CAS No.
- 1962928-26-2
- Chemical Name
- BGC 20-1531 (hydrochloride)
- Synonyms
- AP 1531;AP-1531 hydrochloride;BGC20-1531 (PGN-1531;GTPL3380 hydrochloride;BGC 20-1531 (hydrochloride);BGC201531 hydrochloride(1186532615 free base),BGC 20 1531 hydrochloride(1186532 61 5 free base);4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride
- CBNumber
- CB74666962
- Molecular Formula
- C26H25ClN2O6S
- Formula Weight
- 529
- MOL File
- 1962928-26-2.mol
BGC 20-1531 (hydrochloride) Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 1 mg/ml; DMSO: 1 mg/ml
- form
- A crystalline solid
N-Bromosuccinimide Price
- Product number
- 19742
- Product name
- BGC 20-1531 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19742
- Product name
- BGC 20-1531 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 19742
- Product name
- BGC 20-1531 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- 19742
- Product name
- BGC 20-1531 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $335
- Updated
- 2024/03/01
- Product number
- 5327
- Product name
- BGC20-1531hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $332
- Updated
- 2021/12/16
BGC 20-1531 (hydrochloride) Chemical Properties,Usage,Production
Description
BGC 20-1531 is a potent and selective antagonist of the prostaglandin E2 (PGE2; ) receptor subtype 4 (EP4) with Ki values of 11.7, >10,000, and >10,000 nM for EP4, EP2, and EP3, respectively. It is selective for EP4, exhibiting <50% inhibition at 47 ion channels, cell-surface transporters, enzymes, and nuclear receptors at a concentration of 10 μM. BGC 20-1531 antagonizes PGE2-induced cAMP accumulation in a dose-dependent manner in HEK293 EBNA cells that stably express human EP4 receptors. It also reverses PGE2-induced vasorelaxation (Kb = 15.85 nM) in human middle cerebral and middle meningeal arterial rings. BGC 20-1531 prevents PGE2-induced increases in carotid blood flow and decreases in carotid resistance with an ID50 value of 5 mg/kg in dogs.
Uses
BGC 20-1531 Hydrochloride, is a potent and selective EP4 antagonist, exhibiting <50% inhibition at 47 ion channels, cell-surface transporters, enzymes, and nuclear receptors at a concentration of 10 μM. It also Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arterieshuman middle cerebral and middle meningeal arterial rings.
storage
Desiccate at RT
BGC 20-1531 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
BGC 20-1531 (hydrochloride) Suppliers
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