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BGC 20-1531 (hydrochloride)

Product Name
BGC 20-1531 (hydrochloride)
CAS No.
1962928-26-2
Chemical Name
BGC 20-1531 (hydrochloride)
Synonyms
AP 1531;AP-1531 hydrochloride;BGC20-1531 (PGN-1531;GTPL3380 hydrochloride;BGC 20-1531 (hydrochloride);BGC-20-1531 hydrochloride(1186532-61-5 free base), 10 mM in DMSO;BGC201531 hydrochloride(1186532615 free base),BGC 20 1531 hydrochloride(1186532 61 5 free base);4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride
CBNumber
CB74666962
Molecular Formula
C26H25ClN2O6S
Formula Weight
529
MOL File
1962928-26-2.mol
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BGC 20-1531 (hydrochloride) Property

storage temp. 
Store at -20°C
solubility 
DMF: 1 mg/ml; DMSO: 1 mg/ml
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19742
Product name
BGC 20-1531 (hydrochloride)
Purity
≥98%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
19742
Product name
BGC 20-1531 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
19742
Product name
BGC 20-1531 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
19742
Product name
BGC 20-1531 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$335
Updated
2024/03/01
Tocris
Product number
5327
Product name
BGC20-1531hydrochloride
Purity
≥98%(HPLC)
Packaging
10
Price
$332
Updated
2021/12/16
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BGC 20-1531 (hydrochloride) Chemical Properties,Usage,Production

Description

BGC 20-1531 is a potent and selective antagonist of the prostaglandin E2 (PGE2; ) receptor subtype 4 (EP4) with Ki values of 11.7, >10,000, and >10,000 nM for EP4, EP2, and EP3, respectively. It is selective for EP4, exhibiting <50% inhibition at 47 ion channels, cell-surface transporters, enzymes, and nuclear receptors at a concentration of 10 μM. BGC 20-1531 antagonizes PGE2-induced cAMP accumulation in a dose-dependent manner in HEK293 EBNA cells that stably express human EP4 receptors. It also reverses PGE2-induced vasorelaxation (Kb = 15.85 nM) in human middle cerebral and middle meningeal arterial rings. BGC 20-1531 prevents PGE2-induced increases in carotid blood flow and decreases in carotid resistance with an ID50 value of 5 mg/kg in dogs.

Uses

BGC 20-1531 Hydrochloride, is a potent and selective EP4 antagonist, exhibiting <50% inhibition at 47 ion channels, cell-surface transporters, enzymes, and nuclear receptors at a concentration of 10 μM. It also Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arterieshuman middle cerebral and middle meningeal arterial rings.

storage

Desiccate at RT

BGC 20-1531 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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BGC 20-1531 (hydrochloride) Suppliers

China 25 United Kingdom 1 United States 6 Global 32
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

1962928-26-2, BGC 20-1531 (hydrochloride)Related Search:


  • BGC 20-1531 (hydrochloride)
  • AP 1531
  • BGC20-1531 (PGN-1531
  • 4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride
  • AP-1531 hydrochloride
  • GTPL3380 hydrochloride
  • BGC201531 hydrochloride(1186532615 free base),BGC 20 1531 hydrochloride(1186532 61 5 free base)
  • BGC-20-1531 hydrochloride(1186532-61-5 free base), 10 mM in DMSO
  • 1962928-26-2