SKA-121

Product Name: SKA-121
CAS No.: 1820708-73-3
Chemical Name: SKA-121
Synonyms: SKA-121;SKA121,SKA 121;Naphth[2,1-d]oxazol-2-amine, 5-methyl-;SKA-121 5-Methylnaphtho[2,1-d]oxazol-2-amin
CBNumber: CB74667080
Molecular Formula: C12H10N2O
Formula Weight: 198.22
MOL File: 1820708-73-3.mol

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SKA-121 Property

Boiling point:: 403.2±38.0 °C(Predicted)
Density: 1.302±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
form: powder
pka: 4.48±0.30(Predicted)
color: brown to dark gray

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2206
Product name: SKA-121
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $105
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2206
Product name: SKA-121
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $338
Updated: 2024/03/01

Cayman Chemical

Product number: 9003088
Product name: SKA-121
Purity: ≥98%
Packaging: 1mg
Price: $27
Updated: 2024/03/01

Cayman Chemical

Product number: 9003088
Product name: SKA-121
Purity: ≥98%
Packaging: 25 mg
Price: $565
Updated: 2024/03/01

Cayman Chemical

Product number: 9003088
Product name: SKA-121
Purity: ≥98%
Packaging: 500μg
Price: $43
Updated: 2023/01/06

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SKA-121 Chemical Properties,Usage,Production

Biochem/physiol Actions

SKA-121 is a KCa3.1 (IKCa1, IK1, KCa4, SKCa4, SK4) subtype-selective small conductance Ca2+-activated K+ channel (SK channel) positive-gating modulator (EC50 = 109 nM/KCa3.1 vs. 8.7 μM/KCa2.1, 6.8 μM/KCa2.2, 4.4 μM/KCa2.3) with 200- to 400-fold selectivity over CaV1.2 as well as representative KVs (KV1.3, KV2.1, KV3.1, and KV11.1) and NaV (NaV1.2, NaV1.4, NaV1.5, and NaV1.7) channels. When applied in vivo, SKA-121 significantly lowers mean arterial blood pressure in wild-type, but not KCa3.1(-/-), normotensive and hypertensive mice (100 mg/kg i.p.). SKA-121 is a more potent and selective KCa3.1 activator than SKA-31 (EC50 = 260 nM/KCa3.1, 2.9 μM/KCa2.1, 1.9 μM/KCa2.2, 2.9 μM/KCa2.3).

storage

Store at -20°C

SKA-121 Preparation Products And Raw materials

Raw materials

Preparation Products

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SKA-121 Suppliers

China 28 United States 6 Global 34

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1820708-73-3, SKA-121Related Search:

SKA-121

Naphth[2,1-d]oxazol-2-amine, 5-methyl-

SKA-121 5-Methylnaphtho[2,1-d]oxazol-2-amin

SKA121,SKA 121

1820708-73-3