GNE-6640

Product Name: GNE-6640
CAS No.: 2009273-60-1
Chemical Name: GNE-6640
Synonyms: GNE-6640;USP7-IN-8;GNE-6776 HCl;Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl-;inhibit,USP7,Inhibitor,USP-7-IN-8,Deubiquitinase,DUBs,USP7IN8,anticancer,USP7 IN 8
CBNumber: CB74667954
Molecular Formula: C21H21N3O2
Formula Weight: 347.41
MOL File: 2009273-60-1.mol

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GNE-6640 Property

Boiling point:: 590.1±50.0 °C(Predicted)
Density: 1.210±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 83.33 mg/mL (239.86 mM; Need ultrasonic)
pka: 8.20±0.15(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0159190
Product name: USP7-IN-8
Purity: ≥98.0%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573139
Product name: GNE-6640
Purity: >98%
Packaging: 100mg
Price: $1133.9
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573139
Product name: GNE-6640
Purity: >98%
Packaging: 250mg
Price: $1802
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573139
Product name: GNE-6640
Purity: >98%
Packaging: 1g
Price: $3655
Updated: 2021/12/16

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GNE-6640 Chemical Properties,Usage,Production

Biological Activity

USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects[1]. USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4[1].

References

[1]. Robert Blake, et al. Usp7 inhibitor compounds and methods of use. US20160272588A1.

GNE-6640 Preparation Products And Raw materials

Raw materials

Preparation Products

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GNE-6640 Suppliers

China 11 United States 2 Global 13

Shanghai Beckham Medical Technology Co., Ltd

Tel: 021-13816613772 13816613772
Fax: QQ: 12922499
Email: huahero21@sina.com
Country: China
ProdList: 367
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9708
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8019
Advantage: 62

Hangzhou Synstar pharmaceutical Technology CO.,Ltd

Tel: 0571-85361029
Fax: 0571-85361029
Email: synstar518@163.com
Country: China
ProdList: 1991
Advantage: 58

Taizhou Crene Biotechnology Co. Ltd.

Tel: 0576-88813233 13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 2013
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InvivoChem

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Fax: 708-557-7486
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Country: United States
ProdList: 6393
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15342225168
Email: yutianchun2007@126.com
Country: China
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InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6749
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24017
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12007
Advantage: 58

2009273-60-1, GNE-6640Related Search:

GNE-6640

Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl-

GNE-6776 HCl

USP7-IN-8

inhibit,USP7,Inhibitor,USP-7-IN-8,Deubiquitinase,DUBs,USP7IN8,anticancer,USP7 IN 8

2009273-60-1