GNE-6640

Product Name: GNE-6640
CAS No.: 2009273-60-1
Chemical Name: GNE-6640
Synonyms: GNE-6640;USP7-IN-8;GNE-6776 HCl;Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl-;inhibit,USP7,Inhibitor,USP-7-IN-8,Deubiquitinase,DUBs,USP7IN8,anticancer,USP7 IN 8
CBNumber: CB74667954
Molecular Formula: C21H21N3O2
Formula Weight: 347.41
MOL File: 2009273-60-1.mol

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GNE-6640 Property

Boiling point:: 590.1±50.0 °C(Predicted)
Density: 1.210±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 83.33 mg/mL (239.86 mM; Need ultrasonic)
form: Solid
pka: 8.20±0.15(Predicted)
color: Off-white to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0159190
Product name: USP7-IN-8
Purity: ≥98.0%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573139
Product name: GNE-6640
Purity: >98%
Packaging: 100mg
Price: $1133.9
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573139
Product name: GNE-6640
Purity: >98%
Packaging: 250mg
Price: $1802
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573139
Product name: GNE-6640
Purity: >98%
Packaging: 1g
Price: $3655
Updated: 2021/12/16

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GNE-6640 Chemical Properties,Usage,Production

Biological Activity

USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects[1]. USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4[1].

References

[1]. Robert Blake, et al. Usp7 inhibitor compounds and methods of use. US20160272588A1.

GNE-6640 Preparation Products And Raw materials

Raw materials

Preparation Products

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GNE-6640 Suppliers

China 11 United States 2 Global 13

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

2009273-60-1, GNE-6640Related Search:

GNE-6640

Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl-

GNE-6776 HCl

USP7-IN-8

inhibit,USP7,Inhibitor,USP-7-IN-8,Deubiquitinase,DUBs,USP7IN8,anticancer,USP7 IN 8

2009273-60-1