NCT-506

Product Name: NCT-506
CAS No.: 2231098-99-8
Chemical Name: NCT-506
Synonyms: NCT-506;NCT 506,NCT506;Cyclopropanecarbonitrile, 1-[4-[6-fluoro-3-[[4-(methylsulfonyl)-1-piperazinyl]carbonyl]-4-quinolinyl]phenyl]-
CBNumber: CB74668269
Molecular Formula: C25H23FN4O3S
Formula Weight: 478.54
MOL File: 2231098-99-8.mol

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NCT-506 Property

Boiling point:: 719.9±70.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 33.33 mg/mL (69.65 mM; Need ultrasonic)
pka: 3.74±0.27(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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NCT-506 Chemical Properties,Usage,Production

Biological Activity

NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC50 of 7 nM[1]. NCT-506 inhibits ALDH1A1, hALDH1A3, hALDH2 with IC50s of 0.007±0.001, 16.4±3.99, and 21.5 μM, respectively[1].NCT-506 (100, 10, 1, 0.1 μM, 6 days) decreases significantly cell viability with an EC50 of 45.6 μM in OV-90 cells. NCT-506 inhibits MIA PaCa-2, OV-90, and HT-29 cells with IC50s of 0.077±0.040, 0.161±0.038, and 0.048±0.022 μM in aldefluor cell-based assays, respectively[1]. NCT-506 is treated in combined with Paclitaxel, IC50s of 1202, 924, 870, 411, 102, and 31.8 nM with concentrations of NCT-506 at 0 (DMSO), 1, 3, 10, 20, 30 μM in SKOV-3-TR cells, respectively[1].

References

[1]. Yang SM, et al. Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity. J Med Chem. 2018 Jun 14;61(11):4883-4903.

NCT-506 Preparation Products And Raw materials

Raw materials

Preparation Products

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NCT-506 Suppliers

CHINA 7 United States 4 Global 11

Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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2231098-99-8, NCT-506Related Search:

NCT-506

NCT 506,NCT506

Cyclopropanecarbonitrile, 1-[4-[6-fluoro-3-[[4-(methylsulfonyl)-1-piperazinyl]carbonyl]-4-quinolinyl]phenyl]-

2231098-99-8