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PC945

Product Name
PC945
CAS No.
1931946-73-4
Chemical Name
PC945
Synonyms
PC945;PC-945,PC945;PC945, 10 mM in DMSO;D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[[(4-fluorophenyl)amino]carbonyl]phenyl]-1-piperazinyl]-2-methylphenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-
CBNumber
CB74668335
Molecular Formula
C38H37F3N6O3
Formula Weight
682.75
MOL File
1931946-73-4.mol
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PC945 Property

Density 
1.33±0.1 g/cm3(Predicted)
pka
13.77±0.70(Predicted)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0067758
Product name
PC945
Packaging
5mg
Price
$500
Updated
2021/12/16
ChemScene
Product number
CS-0067758
Product name
PC945
Packaging
100mg
Price
$3600
Updated
2021/12/16
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PC945 Chemical Properties,Usage,Production

Uses

PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC50s of 0.23 μM and 0.22 μM, respectively[1][2].

in vivo

PC945 (0.56-14 μg/mouse; intranasal; daily for 7 days) substantially inhibits the incidence of rolling behavior[1].

Animal Model:Specific-pathogen-free A/J mice (male, 5 weeks old, pulmonary Aspergillus infection)[1]
Dosage:0.56, 2.8, 14 μg/mouse (intranasal application of 0.016-, 0.08-, and 0.4-mg/ml suspensions, respectively)
Administration:Intranasal; daily for 7 days
Result:Substantially inhibited the incidence of rolling behavior.

IC 50

fungal; CYP51A: 0.23 μM (IC50); CYP51B: 0.22 μM (IC50)

References

[1] Colley T, et al. In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02280-16. DOI:10.1128/AAC.02280-16
[2] Colley T, et al. Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection. Sci Rep. 2019 Jul 1;9(1):9482. DOI:10.1038/s41598-019-45890-w

PC945 Preparation Products And Raw materials

Raw materials

Preparation Products

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PC945 Suppliers

CHINA 9 United States 2 Global 11
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
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United States
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32435
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
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sales@hzclap.com
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CHINA
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
Email
customer_service@efebio.com
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China
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11973
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Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
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China
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12000
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RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9835
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58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
29357
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58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
Sales@sangon.com
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China
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6710
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58
Aikon International Limited
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025-58851090 13408877820
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2850281427@qq.com
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China
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10000
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Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
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sales@biosynth.com
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China
ProdList
6051
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
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58

1931946-73-4, PC945Related Search:


  • PC945
  • D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[[(4-fluorophenyl)amino]carbonyl]phenyl]-1-piperazinyl]-2-methylphenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-
  • PC-945,PC945
  • PC945, 10 mM in DMSO
  • 1931946-73-4
  • C38H37F3N6O3