PC945
- Product Name
- PC945
- CAS No.
- 1931946-73-4
- Chemical Name
- PC945
- Synonyms
- PC945;PC-945,PC945;PC945, 10 mM in DMSO;D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[[(4-fluorophenyl)amino]carbonyl]phenyl]-1-piperazinyl]-2-methylphenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-
- CBNumber
- CB74668335
- Molecular Formula
- C38H37F3N6O3
- Formula Weight
- 682.75
- MOL File
- 1931946-73-4.mol
PC945 Property
- Density
- 1.33±0.1 g/cm3(Predicted)
- pka
- 13.77±0.70(Predicted)
- form
- Solid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- CS-0067758
- Product name
- PC945
- Packaging
- 5mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- CS-0067758
- Product name
- PC945
- Packaging
- 100mg
- Price
- $3600
- Updated
- 2021/12/16
PC945 Chemical Properties,Usage,Production
Uses
PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC50s of 0.23 μM and 0.22 μM, respectively[1][2].
in vivo
PC945 (0.56-14 μg/mouse; intranasal; daily for 7 days) substantially inhibits the incidence of rolling behavior[1].
| Animal Model: | Specific-pathogen-free A/J mice (male, 5 weeks old, pulmonary Aspergillus infection)[1] |
| Dosage: | 0.56, 2.8, 14 μg/mouse (intranasal application of 0.016-, 0.08-, and 0.4-mg/ml suspensions, respectively) |
| Administration: | Intranasal; daily for 7 days |
| Result: | Substantially inhibited the incidence of rolling behavior. |
IC 50
fungal; CYP51A: 0.23 μM (IC50); CYP51B: 0.22 μM (IC50)
References
[1] Colley T, et al. In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02280-16. DOI:10.1128/AAC.02280-16
[2] Colley T, et al. Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection. Sci Rep. 2019 Jul 1;9(1):9482. DOI:10.1038/s41598-019-45890-w
PC945 Preparation Products And Raw materials
Raw materials
Preparation Products
PC945 Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58