S55746

Product Name: S55746
CAS No.: 1448584-12-0
Chemical Name: S55746
Synonyms: BLC201;S55746;S55746 (BLC201);BCL-201 (S55746);S55746, 10 mM in DMSO;S55746(S055746,BCL201);S55746 (Synonyms: BLC201);inhibit,BCL-201,Inhibitor,Bcl-2 Family,S55746,S-55746,BCL 201,BCL201,S 55746;N-(4-hydroxyphenyl)-3-[6-[(3S)-3-(morpholin-4-ylmethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]-1,3-benzodioxol-5-yl]-N-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide;(S)-N-(4-Hydroxyphenyl)-3-(6-(3-(morpholinomethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzo[d][1,3]dioxol-5-yl)-N-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide
CBNumber: CB74668476
Molecular Formula: C43H42N4O6
Formula Weight: 710.82
MOL File: 1448584-12-0.mol

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S55746 Property

storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (70.34 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC12163
Product name: S55746(BLC201)
Purity: >98%
Packaging: 100mg
Price: $1300
Updated: 2021/12/16

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S55746 Chemical Properties,Usage,Production

Description

S55746 (Bcl201, Servier-1) is orally available and has been reported to effectively kill cancer cells that overexpress Bcl-2 using both in vitro and in vivo models. Currently, S55746 as a single agent is in phase-I trials in relapsed or refractory CLL patients. As a sensitizing agent, S55746 is currently being tested for a combination use with PI3Kδinhibitor for follicular lymphoma and mantle cell lymphoma.

Uses

S55746 (BCL201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BCL201) has antitumor activity with low toxicity[1].

in vivo

S55746 is a highly efficacious and well-tolerated (even at doses up to 300 mg/kg) orally active BCL-2 inhibitor^[1].
S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth in RS4;11 and Toledo models time- and dose-dependently^[1].

Animal Model:	Female SCID/beige mice implanted subcutaneously with 3×10⁶ Toledo or RS4;11^[1].
Dosage:	20, 50, 100 mg/kg.
Administration:	Oral gavage daily for 7 consecutive days.
Result:	Induced significant anti-tumor activity time- and dose-dependently.

Animal Model:	SCID/beige female mice with RS4;11 tumor xenografts^[1].
Dosage:	25 and 100 mg/kg.
Administration:	Single oral gavage treatment.
Result:	Did not induce platelet loss in vivo at 25 and 100 mg/kg.

IC 50

Bcl-2: 1.3 nM (Ki); Bcl-xL: 520 nM (Ki); Bcl-2: 3.9 nM (Kd); Bcl-xL: 186 nM (Kd)

References

[1] Casara P, et al. S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth. Oncotarget. 2018 Apr 13;9(28):20075-20088. DOI:10.18632/oncotarget.24744

S55746 Preparation Products And Raw materials

Raw materials

Preparation Products

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S55746 Suppliers

China 34 United States 4 Global 38

ShangHai Caerulum Pharma Discovery Co., Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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InvivoChem

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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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1448584-12-0, S55746Related Search:

S55746

S55746(S055746,BCL201)

S55746 (Synonyms: BLC201)

S55746 (BLC201)

N-(4-hydroxyphenyl)-3-[6-[(3S)-3-(morpholin-4-ylmethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]-1,3-benzodioxol-5-yl]-N-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide

BLC201

1-Indolizinecarboxamide, 3-[6-[[(3S)-3,4-dihydro-3-(4-morpholinylmethyl)-2(1H)-isoquinolinyl]carbonyl]-1,3-benzodioxol-5-yl]-5,6,7,8-tetrahydro-N-(4-hydroxyphenyl)-N-phenyl-

inhibit,BCL-201,Inhibitor,Bcl-2 Family,S55746,S-55746,BCL 201,BCL201,S 55746

BCL-201 (S55746)

(S)-N-(4-Hydroxyphenyl)-3-(6-(3-(morpholinomethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzo[d][1,3]dioxol-5-yl)-N-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide , S55746

(S)-N-(4-Hydroxyphenyl)-3-(6-(3-(morpholinomethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzo[d][1,3]dioxol-5-yl)-N-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide

S55746, 10 mM in DMSO

1448584-12-0

C43H42N4O6