DS-437
- Product Name
- DS-437
- CAS No.
- 1674364-87-4
- Chemical Name
- DS-437
- Synonyms
- DS-437;DS-437 (DS437;DS-437 >=98% (HPLC);Adenosine, 5'-S-[2-[[(ethylamino)carbonyl]amino]ethyl]-5'-thio-
- CBNumber
- CB74669958
- Molecular Formula
- C15H23N7O4S
- Formula Weight
- 397.45
- MOL File
- 1674364-87-4.mol
DS-437 Property
- Density
- 1.71±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:125.0(Max Conc. mg/mL);314.5(Max Conc. mM)
- pka
- 13.13±0.70(Predicted)
- form
- powder
- color
- white to beige
Safety
- RIDADR
- UN 2811 6.1 / PGIII
N-Bromosuccinimide Price
- Product number
- SML1516
- Product name
- DS-437
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $105
- Updated
- 2023/06/20
- Product number
- SML1516
- Product name
- DS-437
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $424
- Updated
- 2023/06/20
- Product number
- 29476
- Product name
- DS-437
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 29476
- Product name
- DS-437
- Packaging
- 5mg
- Price
- $105
- Updated
- 2024/03/01
- Product number
- 29476
- Product name
- DS-437
- Packaging
- 10mg
- Price
- $188
- Updated
- 2024/03/01
DS-437 Chemical Properties,Usage,Production
Description
DS-437 is a dual inhibitor of protein arginine methyltransferase 5 (PRMT5) and PRMT7 (IC50s = 5.9 and 6 μM, respectively). It is selective for PRMT5 and PRMT7 over a panel of 29 additional protein, DNA, and RNA methyltransferases at 50 μM, but also inhibits DNMT3A and DNMT3B (IC50s = 52 and 62 μM, respectively). DS-437 (2.5 and 10 μM) inhibits symmetrical arginine dimethylation of FOXP3 in HEK293T cells, as well as symmetrical arginine dimethylation of p60 and the ribonucleoproteins SmD1/D3 and SmB/B’ in MDA-MB-231 cells in a concentration-dependent manner. It inhibits the ability of regulatory T cells (Tregs) to suppress effector T cell (Teff) proliferation in vitro in human and murine Treg suppression assays. DS-437 (10 mg/kg five times per week) reduces tumor growth in a CT26Her2 murine colon cancer model when administered in combination with the anti-p185erbB2/neu antibody 4D5.
Uses
DS-437 has been used as an inhibitor of protein arginine methyltransferase 5 (PRMT5) to study its effect on forkhead box P3 (FOXP3) methylation and regulatory T cells (Tregs) function in 293T cells.
Biochem/physiol Actions
DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC50 5.9 and 6 μM) with little interaction against a panel of 30 other human methyltransferases.
DS-437 Preparation Products And Raw materials
Raw materials
Preparation Products
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