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DS-437

Product Name
DS-437
CAS No.
1674364-87-4
Chemical Name
DS-437
Synonyms
DS-437;DS-437 (DS437;DS-437 >=98% (HPLC);Adenosine, 5'-S-[2-[[(ethylamino)carbonyl]amino]ethyl]-5'-thio-
CBNumber
CB74669958
Molecular Formula
C15H23N7O4S
Formula Weight
397.45
MOL File
1674364-87-4.mol
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DS-437 Property

Density 
1.71±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO:125.0(Max Conc. mg/mL);314.5(Max Conc. mM)
pka
13.13±0.70(Predicted)
form 
powder
color 
white to beige
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Safety

RIDADR 
UN 2811 6.1 / PGIII
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1516
Product name
DS-437
Purity
≥98% (HPLC)
Packaging
5MG
Price
$105
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1516
Product name
DS-437
Purity
≥98% (HPLC)
Packaging
25MG
Price
$424
Updated
2023/06/20
Cayman Chemical
Product number
29476
Product name
DS-437
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
29476
Product name
DS-437
Packaging
5mg
Price
$105
Updated
2024/03/01
Cayman Chemical
Product number
29476
Product name
DS-437
Packaging
10mg
Price
$188
Updated
2024/03/01
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DS-437 Chemical Properties,Usage,Production

Description

DS-437 is a dual inhibitor of protein arginine methyltransferase 5 (PRMT5) and PRMT7 (IC50s = 5.9 and 6 μM, respectively). It is selective for PRMT5 and PRMT7 over a panel of 29 additional protein, DNA, and RNA methyltransferases at 50 μM, but also inhibits DNMT3A and DNMT3B (IC50s = 52 and 62 μM, respectively). DS-437 (2.5 and 10 μM) inhibits symmetrical arginine dimethylation of FOXP3 in HEK293T cells, as well as symmetrical arginine dimethylation of p60 and the ribonucleoproteins SmD1/D3 and SmB/B’ in MDA-MB-231 cells in a concentration-dependent manner. It inhibits the ability of regulatory T cells (Tregs) to suppress effector T cell (Teff) proliferation in vitro in human and murine Treg suppression assays. DS-437 (10 mg/kg five times per week) reduces tumor growth in a CT26Her2 murine colon cancer model when administered in combination with the anti-p185erbB2/neu antibody 4D5.

Uses

DS-437 has been used as an inhibitor of protein arginine methyltransferase 5 (PRMT5) to study its effect on forkhead box P3 (FOXP3) methylation and regulatory T cells (Tregs) function in 293T cells.

Biochem/physiol Actions

DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC50 5.9 and 6 μM) with little interaction against a panel of 30 other human methyltransferases.

DS-437 Preparation Products And Raw materials

Raw materials

Preparation Products

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DS-437 Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32080
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38470
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52925
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1674364-87-4, DS-437Related Search:


  • DS-437
  • DS-437 (DS437
  • Adenosine, 5'-S-[2-[[(ethylamino)carbonyl]amino]ethyl]-5'-thio-
  • DS-437 >=98% (HPLC)
  • 1674364-87-4
  • C15H23N7O4S