5-PHENYLTHIO-1,2-DIAMINOBENZENE

Product Name: 5-PHENYLTHIO-1,2-DIAMINOBENZENE
CAS No.: 43156-48-5
Chemical Name: 5-PHENYLTHIO-1,2-DIAMINOBENZENE
Synonyms: 3,4-DIAMINODIPHENYLSULFIDE;5-PHENYLTHIO-1,2-DIAMINOBENZENE;1,2-diamino-4-phenylthiobenzene;4-(phenylthio)benzene-1,2-diamine;4-(Phenylthio)-o-phenylenediamine;4-(Phenylthio)-1,2-benzenediamine;4-Thiophenoxy-1,2-phenylenediamine;1,2-Benzenediamine, 4-(phenylthio)-;4-PHENYLSULFANYLBENZENE-1,2-DIAMINE;4-Phenylsulfenyl-o-phenylenediamine
CBNumber: CB7468726
Molecular Formula: C12H12N2S
Formula Weight: 216.3
MOL File: 43156-48-5.mol

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5-PHENYLTHIO-1,2-DIAMINOBENZENE Property

Melting point:: >58°C (dec.)
Boiling point:: 441.5±35.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.36±0.10(Predicted)
color: Pale Purple to Purple
Stability:: Air Sensitive
CAS DataBase Reference: 43156-48-5(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P336950
Product name: 4-(Phenylthio)-1,2-benzenediamine
Packaging: 25g
Price: $2395
Updated: 2021/12/16

AK Scientific

Product number: 5970AB
Product name: 4-(Phenylthio)benzene-1,2-diamine
Packaging: 1g
Price: $118
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 48287
Product name: 4-(Phenylthio)-1,2-benzenediamine
Packaging: 5G
Price: $1000
Updated: 2021/12/16

Crysdot

Product number: CD12072124
Product name: 4-(Phenylthio)benzene-1,2-diamine
Purity: 95+%
Packaging: 10g
Price: $347
Updated: 2021/12/16

Alichem

Product number: 43156485
Product name: 4-(Phenylthio)benzene-1,2-diamine
Packaging: 10g
Price: $408.45
Updated: 2021/12/16

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5-PHENYLTHIO-1,2-DIAMINOBENZENE Chemical Properties,Usage,Production

Uses

4-(Phenylthio)-1,2-benzenediamine is used in the synthesis of bis(2-chloroethyl)aminophosphoryl-containing compounds which are potential anticancer agents. It is also used in the synthesis of 2-substituted-2,3-dihyrdro-5-thiophenoxy-1H-1,3,2-benzodiazaphosphole 2-oxides which exhibit antimicrobial activity.

Synthesis

43156-47-4

43156-48-5

General procedure for the synthesis of 4-(phenylthio)benzene-1,2-diamine from 2-nitro-5-phenylmercaptoaniline: 2-nitro-5-phenylmercaptoaniline (36.9 g) and 4 times its weight of ethanol, followed by 0.1 times the weight of platinum-carbon catalyst for 2-nitro-5-phenylmercaptoaniline, were added to a 500 mL four-necked flask equipped with thermometer and stirring device. The hydrogenation reaction was initiated with stirring and heated to 70-90°C under hydrogen atmosphere while pressurized to 1.0-2.0 MPa for 8 hours. Upon completion of the reaction, the platinum carbon catalyst was removed by filtration, followed by evaporation to remove ethanol to afford 4-(phenylthio)benzene-1,2-diamine (21.2 g), which can be used directly in the next step of the reaction.

References

[1] Archiv der Pharmazie, 1983, vol. 316, # 7, p. 638 - 638
[2] Journal of Heterocyclic Chemistry, 2004, vol. 41, # 2, p. 273 - 276
[3] Patent: CN103242238, 2016, B. Location in patent: Paragraph 0039; 0040

5-PHENYLTHIO-1,2-DIAMINOBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-PHENYLTHIO-1,2-DIAMINOBENZENE Suppliers

China 45 India 2 Ukraine 1 United Kingdom 6 United States 11 Global 65

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43156-48-5, 5-PHENYLTHIO-1,2-DIAMINOBENZENERelated Search:

Febantel 4-(2'-Naphthalenethio)-1,2-phenylenediamine N-[2-amino-5-(phenylthio)phenyl]-2-methoxyacetamide 5-PHENYLTHIO-1,2-DIAMINOBENZENE 2-Nitro-5-(phenylthio)aniline

5-PHENYLTHIO-1,2-DIAMINOBENZENE

4-(phenylthio)benzene-1,2-diamine

3,4-DIAMINODIPHENYLSULFIDE

4-Phenylsulfenyl-o-phenylenediamine

4-Thiophenoxy-1,2-phenylenediamine

4-(Phenylthio)-1,2-benzenediamine

4-(Phenylthio)-o-phenylenediamine

4-PHENYLSULFANYLBENZENE-1,2-DIAMINE

1,2-diamino-4-phenylthiobenzene

1,2-Benzenediamine, 4-(phenylthio)-

43156-48-5

Benzene derivates