TAK-041

Product Name: TAK-041
CAS No.: 1929519-13-0
Chemical Name: TAK-041
Synonyms: TAK-041;NBI-1065846;Zelatriazin;TAK-041, 10 mM in DMSO;TAK-041 (Synonyms: NBI-1065846);1,2,3-Benzotriazine-3(4H)-acetamide, 4-oxo-N-[(1S)-1-[4-(trifluoromethoxy)phenyl]ethyl]-;(S)-2-(4-Oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamide;2-(4-oxo-3,4-dihydro-1,2,3-benzotriazin-3-yl)-N-[(1S)-1-[4-(trifluoromethoxy)phenyl]ethyl]acetamide;inhibit,deficits,social,BALB/c,NBI 1065846,NBI1065846,negative,schizophrenia,TAK-041,GPR139,symptoms,interaction,G Protein-Coupled Receptor 139,TAK 041,mouse,TAK041,Inhibitor
CBNumber: CB74694907
Molecular Formula: C18H15F3N4O3
Formula Weight: 392.33
MOL File: 1929519-13-0.mol

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TAK-041 Property

Density: 1.42±0.1 g/cm3(Predicted)
solubility: DMF: 3 mg/ml; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
form: A crystalline solid
pka: 13.89±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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TAK-041 Chemical Properties,Usage,Production

Uses

Zelatriazin (TAK-041; NBI-1065846) is a potent and selective GPR139 agonist with an EC50 of 22 nM. Zelatriazin has the potential for the research of negative symptoms associated with schizophrenia[1].

in vivo

Zelatriazin (0.03-3 mg/kg; P.o.) improves social behavior in BALB/c mice^[1].

Animal Model:	BALB/c mice^[1]
Dosage:	0.03, 0.3, and 3 mg/kg
Administration:	P.o.
Result:	Dose-dependently improved the social behavior of BALB/c mice.

References

[1] Reichard HA, et al. Discovery of TAK-041: a Potent and Selective GPR139 Agonist Explored for the Treatment of Negative Symptoms Associated with Schizophrenia [published online ahead of print, 2021 Jul 14]. J Med Chem. 2021;10.1021/acs.jmedchem.1c00820. DOI:10.1021/acs.jmedchem.1c00820

TAK-041 Preparation Products And Raw materials

Raw materials

Preparation Products

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TAK-041 Suppliers

China 24 United States 3 Global 27

ShangHai Caerulum Pharma Discovery Co., Ltd.

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Shanghai EFE Biological Technology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Shanghai SuperLan Chemcial Technique Centre

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TargetMol Chemicals Inc.

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Guangzhou Younan Technology Co., Ltd

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Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

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Chunchuang (Wuhan) Technology Co., Ltd

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Bide Pharmatech Ltd.

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1929519-13-0, TAK-041Related Search:

TAK-041

NBI-1065846

TAK-041 (Synonyms: NBI-1065846)

(S)-2-(4-Oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamide

inhibit,deficits,social,BALB/c,NBI 1065846,NBI1065846,negative,schizophrenia,TAK-041,GPR139,symptoms,interaction,G Protein-Coupled Receptor 139,TAK 041,mouse,TAK041,Inhibitor

1,2,3-Benzotriazine-3(4H)-acetamide, 4-oxo-N-[(1S)-1-[4-(trifluoromethoxy)phenyl]ethyl]-

Zelatriazin

2-(4-oxo-3,4-dihydro-1,2,3-benzotriazin-3-yl)-N-[(1S)-1-[4-(trifluoromethoxy)phenyl]ethyl]acetamide

TAK-041, 10 mM in DMSO

1929519-13-0