ChemicalBook > CAS DataBase List > CYCLOHEXYL ISOCYANIDE

CYCLOHEXYL ISOCYANIDE

Product Name: CYCLOHEXYL ISOCYANIDE
CAS No.: 931-53-3
Chemical Name: CYCLOHEXYL ISOCYANIDE
Synonyms: HANSA ISN-0519;BIO-FARMA BF001328;ISOCYANOCYCLOHEXANE;CYCLOHEXYL ISONITRILE;CYCLOHEXYL ISOCYANIDE;Cyclohexaneisonitrile;Cyclohexane, isocyano-;Cyclohexyl #niso-cyanide;Cyclohexyl isocyanide,99%;Cyclohexyl isocyanide 98%
CBNumber: CB7469738
Molecular Formula: C7H11N
Formula Weight: 109.17
MOL File: 931-53-3.mol

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CYCLOHEXYL ISOCYANIDE Property

Melting point:: 6.45°C
Boiling point:: 173-176 °C
Density: 0.878 g/mL at 25 °C(lit.)
refractive index: n20/D 1.45(lit.)
Flash point:: 170 °F
storage temp.: Store at +2°C to +8°C.
form: Liquid
color: Clear colorless to slightly brown
BRN: 3662332
Stability:: Stable. Incompatible with strong acids, strong bases, strong reducing agents, strong oxidizing agents. Flammable.
InChI: InChI=1S/C7H11N/c1-8-7-5-3-2-4-6-7/h7H,2-6H2
InChIKey: XYZMOVWWVXBHDP-UHFFFAOYSA-N
SMILES: C1([N+]#[C-])CCCCC1
CAS DataBase Reference: 931-53-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,T
Risk Statements: 20/21/22-23/24/25
Safety Statements: 36/37-45-24/25
RIDADR: UN 2810 6.1/PG 2
WGK Germany: 3
F: 10-13-21
HazardClass: 6.1
PackingGroup: III
HS Code: 29299090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 133302
Product name: Cyclohexyl isocyanide
Purity: 98%
Packaging: 1g
Price: $55.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.18151
Product name: Cyclohexyl isocyanide
Purity: for synthesis
Packaging: 10ML
Price: $164
Updated: 2025/07/31

Sigma-Aldrich

Product number: 133302
Product name: Cyclohexyl isocyanide
Purity: 98%
Packaging: 5g
Price: $128
Updated: 2025/07/31

TCI Chemical

Product number: C1438
Product name: Cyclohexyl Isocyanide
Purity: >98.0%(GC)
Packaging: 1g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: C1438
Product name: Cyclohexyl Isocyanide
Purity: >98.0%(GC)
Packaging: 5g
Price: $139
Updated: 2025/07/31

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CYCLOHEXYL ISOCYANIDE Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Uses

Cyclohexyl Isocyanide can be used as novel arginase inhibitors to treat diseases.

Definition

ChEBI: Cyclohexyl isocyanide is an isocyanide having a cyclohexyl group attached to nitrogen. It is a conjugate base of a cyclohexyl isocyanide(1+).

Preparation

CAUTION: Use a well-ventilated hood and take all precautions before using phosgene.
To a flask equipped as in Preparation 3-1 is added 1.27 kg (10.0 moles) of N-cyclohexylformamide, 3.20 liters of triethylamine, and 4.50 liters of methylene chloride. The solution is stirred while phosgene is rapidly added (300-400 gm/hr) to cause vigorous refluxing. Refluxing ceases after 1.04 kg (10.2 moles) of phosgene have been added and the addition is stopped. The reaction mixture is cooled to 22-25°C, 400 gm (23.5 moles) of ammonia gas added over a period of 1-2 hr, the mixture filtered then concentrated under reduced pressure, and the residue distilled to afford 955 gm (88%), b.p. 67-72°C (14 mm Hg).

General Description

Cyclohexyl isocyanide reacts with dimethyl acetylenedicarboxylate to give a mixture of cyclopenta[b]pyridine derivatives, azaspirononatriene derivative and the azabicyclononatriene. It reacts with dialkyl acetylenedicarboxylates to form 1:1 intermediate which on facile addition to 1-benzylisatin and tryptantrin yields highly functionalized novel unsaturated γ-spiroiminolactones.

References

[1] Khalili, Gholamhossein. “ChemInform Abstract: A Diastereoselective Synthesis of (Z)-3-[(Aryl)(hydroxyimino)methyl] -2-cyclohexyl-1-(cyclohexylamino)imidazo[5,1-a]isoquinolinium Chlorides from Isoquinoline, Chlorooximes, and Cyclohexyl Isocyanide.” ChemInform 47 25 (2016).
[2] M. Anary‐Abbasinejad, M. Heidari, N. Shams. “One-pot synthesis of highly functionalised 1H-pyrazoles from arylcarbohydrazides, cyclohexyl isocyanide, and acetylene diesters.” Arkivoc 2012 1 (2012).
[3] Anary‐Abbasinejad, M. M. Jaafari and Mahdiyeh Talebizadeh. “One-pot Four-component Reaction between Arylamines, Arylglyoxals, Cyclohexyl Isocyanide, and Acetylene Diesters: An Efficient Synthesis of 2H-iminopyran Derivatives.” 2019. 0.
[4] Alireza Hassanabadi. “ChemInform Abstract: Use of Cyclohexyl Isocyanide in the Esterification of N-Benzoyl α-Amino Acid Derivatives.” ChemInform 43 3 (2011).
[5] A. Hassanabadi. “The use of cyclohexyl isocyanide in the esterification of N -benzoyl α-amino acids derivatives.” Journal of Chemical Research-s 18 1 (2011): 468–470.

CYCLOHEXYL ISOCYANIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLOHEXYL ISOCYANIDE Suppliers

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View Lastest Price from CYCLOHEXYL ISOCYANIDE manufacturers

Henan Fengda Chemical Co., Ltd

Product: CYCLOHEXYL ISOCYANIDE 931-53-3
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-26

Shaanxi Dideu Medichem Co. Ltd

Product: Cyclohexyl isocyanide 931-53-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-01-07

Career Henan Chemical Co

Product: CYCLOHEXYL ISOCYANIDE 931-53-3
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100g , 1kg, 5kg , 50kg
Release date: 2020-01-07

931-53-3, CYCLOHEXYL ISOCYANIDERelated Search:

3,4-Diaminobenzoic acid Dimedone Benzyl isocyanide Benzeneacetonitrile Benzyl chloride Benzyl isocyanate CYCLOHEXYL ISOCYANIDE 1-ADAMANTANEISOCYANIDE 4-(N-T-BUTOXYCARBONYLAMINO)CYCLOHEXYLISOCYANIDE 2-(1'-ISOCYANOCYCLOHEXYL) ACETIC ACID METHYL ESTER ETHYL 1-ISOCYANOCYCLOHEXANECARBOXYLATE TRANS-ETHYL-2-ISOCYANO-CYCLOHEXYLCARBOXYLATE (S,S)-1,2-DIISOCYANOCYCLO-HEXANE 1,2-DIISOCYANOCYCLOHEXANE Cyclohexanecarboxylic acid, 1-isocyano-, methyl ester (9CI) CIS-ETHYL-2-ISOCYANOCYCLO-HEXYLCARBOXYLATE BIO-FARMA BF001930 Cyclohexane, 1,4-diisocyano- (9CI)

Cyclohexane, isocyano-

Cyclohexaneisonitrile

BIO-FARMA BF001328

ISOCYANOCYCLOHEXANE

HANSA ISN-0519

CYCLOHEXYL ISOCYANIDE

CYCLOHEXYL ISONITRILE

Cyclohexyl #niso-cyanide

Cyclohexane, isocyano- (9CI)

Cyclohexyl isocyanide 98%

Cyclohexyl isocyanide,99%

Cyclohexyl isocyanide ,98%

CYCLOHEXYL ISOCYANIDE FOR SYNTHESIS

Cyclohexyl Isocyanide &gt

Cyclohexyl isocyanide, 98%, for synthesis

CYCLOHEXYL ISOCYANIDE ISO 9001：2015 REACH

931-53-3

C6H11NC

Building Blocks

Organic Building Blocks

Nitrogen Compounds

Isocyanides

ISONITRITE