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COMPOUND 52

Product Name
COMPOUND 52
CAS No.
212779-48-1
Chemical Name
COMPOUND 52
Synonyms
NG-52;N -52;NG-52, >98%;COMPOUND 52;NG 52 ，S6540;NG 52 (Compound 52 );NG 52, 10 mM in DMSO;NG52; COMPOUND52;NG-52;COMPOUND-52;2-(2-HYDROXYETHYLAMINO)-6-(3-CHLORANILINO)-9-ISOPROPYLPURINE;2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol
CBNumber
CB7469930
Molecular Formula
C16H19ClN6O
Formula Weight
346.81
MOL File
Mol file
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COMPOUND 52 Property

Boiling point:
587.7±60.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
methylene chloride: 50 mg/mL, clear, colorless
form 
powder
pka
14.54±0.10(Predicted)
color 
white to off-white
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Safety

Hazard Codes 
Xn
Risk Statements 
40-68
Safety Statements 
36/37
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17309
Product name
NG 52
Purity
≥98%
Packaging
500μg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
17309
Product name
NG 52
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
17309
Product name
NG 52
Purity
≥98%
Packaging
5mg
Price
$266
Updated
2024/03/01
Cayman Chemical
Product number
17309
Product name
NG 52
Purity
≥98%
Packaging
10mg
Price
$458
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
KIN0001264
Product name
COMPOUND 52
Purity
95.00%
Packaging
1MG
Price
$165.9
Updated
2021/12/16
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COMPOUND 52 Chemical Properties,Usage,Production

Description

NG 52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p (IC50s = 7 and 2 μM, respectively). It is ineffective against the yeast kinases Kin28p, Srb10, and Cak1p. NG 52 is cell permeable and inhibits the growth of S. cerevisiae (GI50 = 30 μM). It is an analog of purvalanol A , a potent inhibitor of mammalian cyclin-dependent kinases.

Uses

NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p[1][2].

in vivo

NG 52 (50-150 mg/kg; oral administration; daily; for 13 days) treatment dose-dependently suppresses the growth of glioma xenograft[2].

Animal Model:Female nu/nu mice (5-week-old) injected with glioma cells[2]
Dosage:50 mg/kg, 100 mg/kg, 150 mg/kg
Administration:Oral administration; daily; for 13 days
Result:Dose-dependently suppressed the growth of glioma xenograft.

IC 50

cdc2-cyclin B: 0.34 μM (IC50); Pho85p: 2 nM (IC50); Cdc28p: 7 μM (IC50); Phosphoglycerate kinase 1 (PGK1): 2.5 μM (IC50)

References

[1] ray NS, Wodicka L, Thunnissen AM et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8. DOI:10.1126/science.281.5376.533
[2] Wen-Liang Wang, et al. Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52. Acta Pharmacol Sin. 2020 Jul 31. DOI:10.1038/s41401-020-0465-8

COMPOUND 52 Preparation Products And Raw materials

Raw materials

Preparation Products

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COMPOUND 52 Suppliers

China 71 India 1 Switzerland 2 United Kingdom 1 United States 13 Global 88
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

212779-48-1, COMPOUND 52Related Search:

CHLOROPHENYLSILANE 4,4'-DDT

  • NG-52
  • 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLORANILINO)-9-ISOPROPYLPURINE
  • 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE
  • COMPOUND 52
  • 2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine, NG-52
  • 2-((6-((3-chlorophenyl)aMino)-9-isopropyl-9H-purin-2-yl)aMino)ethanol
  • 2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]ethanol
  • NG 52 (Compound 52 )
  • 2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol
  • NG52; COMPOUND52;NG-52;COMPOUND-52
  • NG-52, >98%
  • Ethanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-
  • cdc2-cyclin B,Cyclin dependent kinase,yeast,Pho85p,PGK1,CDK,Cdc28p,anti-proliferation,glioma,inhibit,Compound-52,ROS,ATP,Warburg,Compound52,CDK2,NG 52,ATP-compatible,PDHK1,Inhibitor
  • N -52
  • NG 52, 10 mM in DMSO
  • NG 52 ，S6540
  • 212779-48-1
  • C16H19ClN6O
  • BioChemical
  • Cell Cycle Regulators
  • Cell Cycle
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Apoptosis and Cell Cycle
  • Inhibitors