ChemicalBook > CAS DataBase List > IRBP (1-20), human

IRBP (1-20), human

Product Name: IRBP (1-20), human
CAS No.: 298202-25-2
Chemical Name: IRBP (1-20), human
Synonyms: Irbp (1-20);IRBP (1-20), human;L-Aspartic acid, glycyl-L-prolyl-L-threonyl-L-histidyl-L-leucyl-L-phenylalanyl-L-glutaminyl-L-prolyl-L-seryl-L-leucyl-L-valyl-L-leucyl-L-α-aspartyl-L-methionyl-L-alanyl-L-lysyl-L-valyl-L-leucyl-L-leucyl-
CBNumber: CB74713738
Molecular Formula: C101H164N24O28S
Formula Weight: 2194.62
MOL File: 298202-25-2.mol

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IRBP (1-20), human Property

Boiling point:: 2184.9±65.0 °C(Predicted)
Density: 1.275±0.06 g/cm3(Predicted)
pka: 2.89±0.10(Predicted)
form: Solid
color: White to off-white
Sequence: Gly-Pro-Thr-His-Leu-Phe-Gln-Pro-Ser-Leu-Val-Leu-Asp-Met-Ala-Lys-Val-Leu-Leu-Asp

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Hazard and Precautionary Statements (GHS)

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IRBP (1-20), human Chemical Properties,Usage,Production

Uses

IRBP (1-20), human contains a major epitope for the H-2b haplotype. IRBP (1-20), human induces experimental autoimmune uveoretinitis (EAU) in H-2b mice[1][2].

in vivo

IRBP (1-20), human TFA induces EAU^[2].
For determination of proliferative and cytokine responses, lymph node and spleen cells are collected 21 days after immunization and are stimulated in culture with the appropriate antigen. Cells of C57BL/6 mice and 129/J mice immunized with IRBP (1-20), human TFA proliferated in response to the peptide^[2].

Animal Model:	C57BL/6 (H-2^bb[2]
Dosage:	200, 300 μg
Administration:	I.h.; After 21 days
Result:	C57BL/6 (H-2^bb) also developed disease, albeit with a lower average score than C57BL/6.

References

[1] Avichezer D, et al. Residues 1-20 of IRBP and whole IRBP elicit different uveitogenic and immunological responses in interferon gamma deficient mice. Exp Eye Res. 2000;71(2):111‐118. DOI:10.1006/exer.2000.0860
[2] Avichezer D, Silver PB, Chan CC, Wiggert B, Caspi RR. Identification of a new epitope of human IRBP that induces autoimmune uveoretinitis in mice of the H-2b haplotype. Invest Ophthalmol Vis Sci. 2000;41(1):127‐131. PMID:10634611

IRBP (1-20), human Preparation Products And Raw materials

Raw materials

Preparation Products

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IRBP (1-20), human Suppliers

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298202-25-2, IRBP (1-20), humanRelated Search:

IRBP (1-20), human

L-Aspartic acid, glycyl-L-prolyl-L-threonyl-L-histidyl-L-leucyl-L-phenylalanyl-L-glutaminyl-L-prolyl-L-seryl-L-leucyl-L-valyl-L-leucyl-L-α-aspartyl-L-methionyl-L-alanyl-L-lysyl-L-valyl-L-leucyl-L-leucyl-

Irbp (1-20)

298202-25-2

C101H164N24O28S