TRPM8 Antagonist

Product Name: TRPM8 Antagonist
CAS No.: 259674-19-6
Chemical Name: TRPM8 Antagonist
Synonyms: TRPM8 Antagonist;TRPM8 antagonist 2;TRPM8 ANTAGONIST;259674-19-6;TRPM8 antagonist 2, 10 mM in DMSO;Methyl N,N-dibenzyl-L-tryptophanate;Methyl Na,Na-dibenzyl-L-tryptophanate;L-Tryptophan, N,N-bis(phenylmethyl)-, methyl ester;TRPM8 antagonist 2,inhibit,Transient receptor potential channels,TRP Channel,Inhibitor,TRPM-8 antagonist 2
CBNumber: CB74718445
Molecular Formula: C26H26N2O2
Formula Weight: 398.5
MOL File: 259674-19-6.mol

More

Less

TRPM8 Antagonist Property

Boiling point:: 567.5±50.0 °C(Predicted)
Density: 1.195±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO : 160 mg/mL (401.51 mM)
pka: 17.02±0.30(Predicted)
form: Solid
color: Light yellow to yellow

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Matrix Scientific

Product number: 295041
Product name: Methyl Na,Na-dibenzyl-L-tryptophanate
Packaging: 100.00mg
Price: $126
Updated: 2026/05/19

Matrix Scientific

Product number: 295041
Product name: Methyl Na,Na-dibenzyl-L-tryptophanate
Packaging: 250.00mg
Price: $247
Updated: 2026/05/19

Matrix Scientific

Product number: 295041
Product name: Methyl Na,Na-dibenzyl-L-tryptophanate
Packaging: 1.00g
Price: $855
Updated: 2026/05/19

DC Chemicals

Product number: DC11472
Product name: TRPM8 antagonist 14
Purity: >98%
Packaging: 100mg
Price: $700
Updated: 2026/05/24

DC Chemicals

Product number: DC11472
Product name: TRPM8 antagonist 14
Purity: >98%
Packaging: 250mg
Price: $1200
Updated: 2026/05/24

More

Less

TRPM8 Antagonist Chemical Properties,Usage,Production

Uses

TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.

in vivo

TRPM8 antagonist 2 (1, 10, and 30 mg/kg, s.c.) shows a marked, dose-dependent antinociceptive activity, and inhibits wet-dog shakes (WDS)-like cold hypersensitivity in mice by 63% at 30 mg/kg. In addition, TRPM8 antagonist 2 (0.1 and 1 μg, s.c.) attenuates Oxaliplatin (OXP)-induced cold allodynia in mice^[1].

References

[1] Bertamino A, et al. Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity. J Med Chem. 2018 Jul 10. doi: 10.1021/acs.jmedchem.8b00545. DOI:10.1021/acs.jmedchem.8b00545

TRPM8 Antagonist Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

TRPM8 Antagonist Suppliers

China 49 United States 5 Global 54

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4847
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 974
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 89686
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7999
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2971
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: QQ：65489617 19372819560
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9621
Advantage: 58

Heze Development Zone chuangli Chemical Co., Ltd.

Tel: 0530-+86-530-529 6766，+86-15666160102 15666160102
Fax: 0530-529 6766
Email: info@chuangli-chem.com
Country: China
ProdList: 852
Advantage: 55

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Taizhou Crene Biotechnology Co. Ltd.

Tel: +86-0576-88813233 +86-13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 1982
Advantage: 58

259674-19-6, TRPM8 AntagonistRelated Search:

TRPM8 Antagonist

TRPM8 ANTAGONIST;259674-19-6

TRPM8 antagonist 2

L-Tryptophan, N,N-bis(phenylmethyl)-, methyl ester

Methyl N,N-dibenzyl-L-tryptophanate

Methyl Na,Na-dibenzyl-L-tryptophanate

TRPM8 antagonist 2,inhibit,Transient receptor potential channels,TRP Channel,Inhibitor,TRPM-8 antagonist 2

TRPM8 antagonist 2, 10 mM in DMSO

259674-19-6

API