TRPM8 Antagonist

Product Name: TRPM8 Antagonist
CAS No.: 259674-19-6
Chemical Name: TRPM8 Antagonist
Synonyms: TRPM8 Antagonist;TRPM8 antagonist 2;TRPM8 ANTAGONIST;259674-19-6;TRPM8 antagonist 2, 10 mM in DMSO;Methyl N,N-dibenzyl-L-tryptophanate;Methyl Na,Na-dibenzyl-L-tryptophanate;L-Tryptophan, N,N-bis(phenylmethyl)-, methyl ester;TRPM8 antagonist 2,inhibit,Transient receptor potential channels,TRP Channel,Inhibitor,TRPM-8 antagonist 2
CBNumber: CB74718445
Molecular Formula: C26H26N2O2
Formula Weight: 398.5
MOL File: 259674-19-6.mol

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TRPM8 Antagonist Property

Boiling point:: 567.5±50.0 °C(Predicted)
Density: 1.195±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO : 160 mg/mL (401.51 mM)
pka: 17.02±0.30(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0046046
Product name: TRPM8antagonist2
Purity: 98.20%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0046046
Product name: TRPM8antagonist2
Purity: 98.20%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0046046
Product name: TRPM8antagonist2
Purity: 98.20%
Packaging: 50mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-0046046
Product name: TRPM8antagonist2
Purity: 98.20%
Packaging: 100mg
Price: $700
Updated: 2021/12/16

DC Chemicals

Product number: DC11472
Product name: TRPM8antagonist14
Purity: >98%
Packaging: 250mg
Price: $1200
Updated: 2021/12/16

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TRPM8 Antagonist Chemical Properties,Usage,Production

Uses

TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.

in vivo

TRPM8 antagonist 2 (1, 10, and 30 mg/kg, s.c.) shows a marked, dose-dependent antinociceptive activity, and inhibits wet-dog shakes (WDS)-like cold hypersensitivity in mice by 63% at 30 mg/kg. In addition, TRPM8 antagonist 2 (0.1 and 1 μg, s.c.) attenuates Oxaliplatin (OXP)-induced cold allodynia in mice^[1].

References

[1] Bertamino A, et al. Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity. J Med Chem. 2018 Jul 10. doi: 10.1021/acs.jmedchem.8b00545. DOI:10.1021/acs.jmedchem.8b00545

TRPM8 Antagonist Preparation Products And Raw materials

Raw materials

Preparation Products

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TRPM8 Antagonist Suppliers

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259674-19-6, TRPM8 AntagonistRelated Search:

TRPM8 Antagonist

TRPM8 ANTAGONIST;259674-19-6

TRPM8 antagonist 2

L-Tryptophan, N,N-bis(phenylmethyl)-, methyl ester

Methyl N,N-dibenzyl-L-tryptophanate

Methyl Na,Na-dibenzyl-L-tryptophanate

TRPM8 antagonist 2,inhibit,Transient receptor potential channels,TRP Channel,Inhibitor,TRPM-8 antagonist 2

TRPM8 antagonist 2, 10 mM in DMSO

259674-19-6

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