ChemicalBook > CAS DataBase List > CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2

CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2

Product Name
CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2
CAS No.
60786-59-6
Chemical Name
CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2
Synonyms
TGOT;(THR4;GLY7)-OXYTOCIN;[THR4, GLY7] OT;thr(4)-gly(7)-oxytoci;[THR4, GLY7]-OXYTOCIN;Thr4, Gly7]-Oxytocin、TGOT;3,3-DiallylthiacarbocyanineBromide;CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2;H-CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2
CBNumber
CB7472530
Molecular Formula
C39H61N11O12S2
Formula Weight
940.1
MOL File
60786-59-6.mol
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CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2 Property

Boiling point:
1489.4±65.0 °C(Predicted)
Density 
1.265±0.06 g/cm3(Predicted)
storage temp. 
−20°C
form 
Solid
pka
9.90±0.15(Predicted)
color 
White to off-white
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Safety

Hazard Codes 
Xn
Risk Statements 
20
Safety Statements 
36/37/39-45
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Hazard statements

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
PRK0000299
Product name
(THR4GLY7)-OXYTOCIN
Purity
95.00%
Packaging
1MG
Price
$606.38
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PRK0000299
Product name
(THR4GLY7)-OXYTOCIN
Purity
95.00%
Packaging
5MG
Price
$716
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PRK0000299
Product name
(THR4GLY7)-OXYTOCIN
Purity
95.00%
Packaging
1G
Price
$850
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PRK0000299
Product name
(THR4GLY7)-OXYTOCIN
Purity
95.00%
Packaging
2.5G
Price
$940
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PRK0000299
Product name
(THR4GLY7)-OXYTOCIN
Purity
95.00%
Packaging
5G
Price
$1005.43
Updated
2021/12/16
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CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2 Chemical Properties,Usage,Production

Uses

(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+ channels. [1][2].

in vivo

(Thr4,Gly7)-Oxytocin (1 μM, direct intra-PVT infusion for 1 min) evokes depolarization on TGOT-responsive neurons in mice[1].
(Thr4,Gly7)-Oxytocin (100 ng, intracerebroventrical injection) increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats[3].

Animal Model:Swiss Webster mice [1]
Dosage:1 μM
Administration:Intratracheal administration for 24 h
Result:Excited 34.3% of aPVT neurons, 57.6% of mPVT neurons, and 60.0% of pPVT neurons.
Increased the firing rate of TGOT-responsive PVT neurons in all subregions.

References

[1] Lily R Barrett, et al. Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Neuropsychopharmacology. 2021 Apr;46(5):1045-1056. DOI:10.1038/s41386-021-00961-3
[2] Binqi Hu, et al. Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms. Cereb Cortex. 2021 Mar 31;31(5):2402-2415. DOI:10.1093/cercor/bhaa363
[3] M R Melis, et al. Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats: correlation with penile erection and yawning. Regul Pept. 1997 Mar 26;69(2):105-11. DOI:10.1016/s0167-0115(97)00002-5

CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2 Suppliers

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60786-59-6, CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2Related Search:

Oxytocin acetate (PHE2,ORN8)-OXYTOCIN Oxytocin free acid Oxytocin Impurtiy ISOTOCIN Oxytocin UROFOLLITROPIN CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2

  • thr(4)-gly(7)-oxytoci
  • [THR4, GLY7] OT
  • [THR4, GLY7]-OXYTOCIN
  • CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2
  • H-CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2
  • H-CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2, (DISULFIDE BOND)
  • 3,3-DiallylthiacarbocyanineBromide
  • Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 (Disulfide bridge Cys1-Cys6)
  • TGOT
  • (THR4
  • GLY7)-OXYTOCIN
  • Glycinamide, L-cysteinyl-L-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-L-cysteinylglycyl-L-leucyl-, cyclic (1→6)-disulfide
  • (Thr4,Gly7)-Oxytocin H-Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 (Disulfide bond)
  • Thr4, Gly7]-Oxytocin、TGOT
  • 60786-59-6
  • C39H61N11O12S2
  • Pituitary Hormones
  • Oxytocin
  • Hormones
  • Cytokines, Growth Factors and Hormones
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical