4,4'-DIMETHOXYCHALCONE

Product Name: 4,4'-DIMETHOXYCHALCONE
CAS No.: 2373-89-9
Chemical Name: 4,4'-DIMETHOXYCHALCONE
Synonyms: Nsc 87339;Ai3-25492;4,4'-Dimethoxychalcone;4,4'-Dimethoxychalcone;DIMETHOXYCHALCONE,4,4'-;4,4''-Dimethoxychalcone;4,4'-Dimethoxychalcone,99%;DIMETHOXYCHALCONE,4,4'-(RG);4,4'-DIMETHOXYBENZYLIDENEACETOPHENONE;4,4''-Dimethoxychalcone, 10 mM in DMSO
CBNumber: CB7473401
Molecular Formula: C17H16O3
Formula Weight: 268.31
MOL File: 2373-89-9.mol

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4,4'-DIMETHOXYCHALCONE Property

Melting point:: 101°C
Boiling point:: 444.6±45.0 °C(Predicted)
Density: 1.128±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 250 mg/mL (931.76 mM)
form: Solid
color: Light yellow to yellow
BRN: 1622293
CAS DataBase Reference: 2373-89-9(CAS DataBase Reference)

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Safety

HS Code: 29145090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S617237
Product name: 4,4'-DIMETHOXYCHALCONE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: S617237
Product name: 4,4'-DIMETHOXYCHALCONE
Purity: Aldrich
Packaging: 25mg
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: B6793
Product name: 4,4'-Dimethoxychalcone
Packaging: 5G
Price: $115
Updated: 2025/07/31

TCI Chemical

Product number: B6793
Product name: 4,4'-Dimethoxychalcone
Packaging: 25G
Price: $345
Updated: 2025/07/31

AK Scientific

Product number: 5516AH
Product name: 4,4'-Dimethoxychalcone
Packaging: 5g
Price: $27
Updated: 2021/12/16

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4,4'-DIMETHOXYCHALCONE Chemical Properties,Usage,Production

Uses

4,4'-Dimethoxychalcone acts as a natural autophagy inducer with anti-ageing properties[1].

in vivo

The flavonoid 4,4'-Dimethoxychalcone acts as an anti-ageing compound with cardioprotective effects in mice and the potential to promote longevity across species^[1].
? 4,4'-Dimethoxychalcone (100?mg/kg; intraperitoneally) efficiently triggered autophagic flux in the heart and liver from wild type (WT) C57BL/6 mice^[1].

Animal Model:	6-week-old male wild type C57BL/6 or Atg4b^-/- mice^[1]
Dosage:	100?mg/kg
Administration:	Injected intraperitoneally with a single
Result:	Triggered autophagic flux in the heart and liver.

References

[1] Carmona-Gutierrez D, et al. The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 2019 Feb 19;10(1):651. DOI:10.1038/s41467-019-08555-w

4,4'-DIMETHOXYCHALCONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4'-DIMETHOXYCHALCONE Suppliers

China 79 Europe 1 Germany 2 India 6 United Kingdom 8 United States 15 Global 111

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2373-89-9, 4,4'-DIMETHOXYCHALCONERelated Search:

3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE 3'-BENZYLOXY-4',5,6,7-TETRAMETHOXYFLAVONE KAEMPFEROL-3,7,4'-TRIMETHYL ETHER SCUTELLAREIN TETRAMETHYL ETHER Hesperidin methylchalcone 3,7,3',4'-TETRAMETHYLGOSSYPETIN EUPATORIN-5-METHYL ETHER DIHYDROXY-4,4'-DIMETHOXYCHALCONE, 2',6'-,2',6'-DIHYDROXY-4,4'-DIMETHOXYCHALCONE 5-HYDROXY-7,4'-DIMETHOXY-6,8-DIMETHYLFLAVONE 2'-HYDROXY-4,4',6'-TRIMETHOXYCHALCONE QUERCETIN-3,7,3',4'-TETRAMETHYL ETHER 3',4',5',6,7,8-HEXAMETHOXY-5-HYDROXYFLAVONE Diosmin 3,4-DIMETHOXYCHALCONE,DIMETHOXYCHALCONE,3,4- 2',4-DIHYDROXY-4',6'-DIMETHOXYCHALCONE Pashanone 3,4'-DIMETHOXYCHALCONE,DIMETHOXYCHALCONE,3,4-(RG) Tangeretin

1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE

2-Propen-1-one, 1,3-bis(4-methoxyphenyl)-

Ai3-25492

Nsc 87339

4,4'-DIMETHOXYBENZYLIDENEACETOPHENONE

DIMETHOXYCHALCONE,4,4'-

(E)-1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE

4,4'-Dimethoxychalcone,99%

DIMETHOXYCHALCONE,4,4'-(RG)

JR-6811, (E)-1,3-bis(4-Methoxyphenyl)prop-2-en-1-one, 97%

(E)-1,3-bis(4-methoxyphenyl)-2-propen-1-one

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4,4'-Dimethoxychalcone

4,4''-Dimethoxychalcone

4,4''-Dimethoxychalcone, 10 mM in DMSO

4,4'-Dimethoxychalcone

2373-89-9

Chalcones