ChemicalBook > CAS DataBase List > N-[4-(adamantan-1-yl)phenyl]-2-(4H-1,2,4-triazol-3-ylsulfanyl)acetamide

N-[4-(adamantan-1-yl)phenyl]-2-(4H-1,2,4-triazol-3-ylsulfanyl)acetamide

Product Name
N-[4-(adamantan-1-yl)phenyl]-2-(4H-1,2,4-triazol-3-ylsulfanyl)acetamide
CAS No.
896657-58-2
Chemical Name
N-[4-(adamantan-1-yl)phenyl]-2-(4H-1,2,4-triazol-3-ylsulfanyl)acetamide
Synonyms
MGH-CP1 ，S9735;MGH-CP1, 10 mM in DMSO;2-((1H-1,2,4-Triazol-5-yl)thio)-N-(4-(adamantan-1-yl)phenyl)acetamide;N-[4-(adamantan-1-yl)phenyl]-2-(4H-1,2,4-triazol-3-ylsulfanyl)acetamide;N-?[4-?(1-?Adamantyl)?phenyl]?-?2-?(4H-?1,?2,?4-?triazol-?3-?ylsulfanyl)?acetamide;MGH CP1,Lats1/2 deletion,Myc,MGHCP1,TEAD auto-palmitoylation,Apoptosis,Epithelial,MGH-CP1,inhibit,Inhibitor,MGH-CP-1
CBNumber
CB74764927
Molecular Formula
C20H24N4OS
Formula Weight
368.49576
MOL File
896657-58-2.mol
More
Less

N-[4-(adamantan-1-yl)phenyl]-2-(4H-1,2,4-triazol-3-ylsulfanyl)acetamide Property

storage temp. 
4°C, away from moisture and light
form 
Solid
color 
White to off-white
InChI
InChI=1S/C20H24N4OS/c25-18(11-26-19-21-12-22-24-19)23-17-3-1-16(2-4-17)20-8-13-5-14(9-20)7-15(6-13)10-20/h1-4,12-15H,5-11H2,(H,23,25)(H,21,22,24)
InChIKey
UUKXOVBCMOZQNC-UHFFFAOYSA-N
SMILES
C(NC1=CC=C(C23CC4CC(CC(C4)C2)C3)C=C1)(=O)CSC1NC=NN=1
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TRC
Product number
A220020
Product name
N-​[4-​(1-​Adamantyl)​phenyl]​-​2-​(4H-​1,​2,​4-​triazol-​3-​ylsulfanyl)​acetamide
Packaging
250mg
Price
$1155
Updated
2021/12/16
More
Less

N-[4-(adamantan-1-yl)phenyl]-2-(4H-1,2,4-triazol-3-ylsulfanyl)acetamide Chemical Properties,Usage,Production

Uses

N-[4-(1-Adamantyl)phenyl]-2-(4H-1,2,4-triazol-3-ylsulfanyl)acetamide acts as a TEAD transcription factor autopalmitoylation inhibitor which may be a therapeutical treatment for certain cancers.

in vivo

MGH-CP1 (75mg/kg; PO; daily, for 2 weeks) inhibits the palmitoylation of TEAD proteins in the intestinal epithelium in wild-type mice, but inhibits upregulation of the TEAD target genes, CTGF and ANKRD1, in Lats1/2 KO mice intestine[1].

Animal Model:Mice (induced high-dose Cre recombination by intraperitoneal injection of 120mg/kg Tamoxifen for two consecutive days)[1]
Dosage:75 mg/kg
Administration:PO; daily, for 2 weeks
Result:Effectively inhibited the palmitoylation of TEAD proteins in the intestinal epithelium in wild-type mice, but effectively inhibited upregulation of the TEAD target genes, CTGF and ANKRD1, in Lats1/2 KO mice intestine.

N-[4-(adamantan-1-yl)phenyl]-2-(4H-1,2,4-triazol-3-ylsulfanyl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-[4-(adamantan-1-yl)phenyl]-2-(4H-1,2,4-triazol-3-ylsulfanyl)acetamide Suppliers

China 31 United States 4 Global 35
Wuhan Huarui Zhicheng Biotechnology Research Co., Ltd
Tel
13638626556
Email
hrzc2022@163.com
Country
China
ProdList
34
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185;
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
Advantage
58
Guangzhou Zhiya Chemdrugs Co.,Ltd
Tel
18122150900
Fax
QQ:2869377561
Email
sculk28@163.com
Country
China
ProdList
646
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Aikon International Limited
Tel
025-58851090 15955137747
Fax
(6)02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15949
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
Advantage
58
Henan Weitesi Chemical Technology Co. LTD
Tel
0371-55135753 18003832934
Fax
2853979818
Email
3842570495@qq.com
Country
China
ProdList
9978
Advantage
58
cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
Country
China
ProdList
10503
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58

896657-58-2, N-[4-(adamantan-1-yl)phenyl]-2-(4H-1,2,4-triazol-3-ylsulfanyl)acetamideRelated Search:


  • N-[4-(adamantan-1-yl)phenyl]-2-(4H-1,2,4-triazol-3-ylsulfanyl)acetamide
  • 2-((1H-1,2,4-Triazol-5-yl)thio)-N-(4-(adamantan-1-yl)phenyl)acetamide
  • N-?[4-?(1-?Adamantyl)?phenyl]?-?2-?(4H-?1,?2,?4-?triazol-?3-?ylsulfanyl)?acetamide
  • MGH CP1,Lats1/2 deletion,Myc,MGHCP1,TEAD auto-palmitoylation,Apoptosis,Epithelial,MGH-CP1,inhibit,Inhibitor,MGH-CP-1
  • MGH-CP1, 10 mM in DMSO
  • MGH-CP1 ，S9735
  • 896657-58-2