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AP521

Product Name
AP521
CAS No.
151227-08-6
Chemical Name
AP521
Synonyms
AP521;AP521,AP-521;N-(1,3-Benzodioxol-5-ylmethyl)-1,2,3,4-tetrahydro-[1]benzothiolo[2,3-c]pyridine-3-carboxamide hydrochloride
CBNumber
CB74796632
Molecular Formula
C20H19ClN2O3S
Formula Weight
402.89
MOL File
151227-08-6.mol
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AP521 Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CCH0007832
Product name
(4R)-N-(2H-1,3-BENZODIOXOL-5-YLMETHYL)-8-THIA-5-AZATRICYCLO[7.4.0.0(2,7)]TRIDECA-1(9),2(7),10,12-TETRAENE-4-CARBOXAMIDE HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$503.47
Updated
2021/12/16
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AP521 Chemical Properties,Usage,Production

Uses

AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM.

in vivo

AP521 significantly increases the number of shock acceptances [F(5,105)=4.46, P<0.01] at doses between 0.5 to 10 mg/kg. Oral administration of AP521 at 3 and 10 mg/kg significantly decreases freezing time [F(3,60)=2.89, P<0.05]. AP521 significantly increases the time spent on the open arms by approximately 2-fold as compare to the vehicle treated group [F(3, 36)=4.21, P<0.05 for AP521]. The anxiolytic-like effect of AP521 appears to be dose-related. AP521 significantly increases the extracellular 5-HT level of the medial prefrontal cortex (mPFC) at 10 mg/kg from 0.5 to 1 h after administration. AP521 at 3 mg/kg tends to increase the extracellular 5-HT level, however, this increase is not significant[1].

IC 50

5-HT1A Receptor: 94 nM (IC50, in human); 5-HT1A Receptor: 135 nM (IC50, in rat); 5-HT1B Receptor: 254 nM (IC50, in rat); 5-HT1B Receptor: 5530 nM (IC50, in human); 5-HT1D Receptor: 418 nM (IC50, in human); 5-HT5A Receptor: 422 nM (IC50, in human); 5-HT7 Receptor: 198 nM (IC50, in rat)

References

[1] Kasahara K, et al. The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats. J Pharmacol Sci. 2015 Jan;127(1):109-16. DOI:10.1016/j.jphs.2014.11.008

AP521 Preparation Products And Raw materials

Raw materials

Preparation Products

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AP521 Suppliers

China 8 United States 5 Global 13
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151227-08-6, AP521Related Search:


  • AP521
  • AP521,AP-521
  • N-(1,3-Benzodioxol-5-ylmethyl)-1,2,3,4-tetrahydro-[1]benzothiolo[2,3-c]pyridine-3-carboxamide hydrochloride
  • 151227-08-6