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FN-1501

Product Name
FN-1501
CAS No.
1429515-59-2
Chemical Name
FN-1501
Synonyms
FN-1501, 10 mM in DMSO;4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide;1H-Pyrazole-3-carboxamide, N-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-
CBNumber
CB74796652
Molecular Formula
C22H25N9O
Formula Weight
431.49
MOL File
1429515-59-2.mol
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FN-1501 Property

Density 
1.427±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 50 mg/mL (115.88 mM)
form 
Solid
pka
11.73±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0039834
Product name
FN-1501
Purity
99.71%
Packaging
5mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0039834
Product name
FN-1501
Purity
99.71%
Packaging
10mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0039834
Product name
FN-1501
Purity
99.71%
Packaging
50mg
Price
$1400
Updated
2021/12/16
ChemScene
Product number
CS-0039834
Product name
FN-1501
Purity
99.71%
Packaging
100mg
Price
$2100
Updated
2021/12/16
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FN-1501 Chemical Properties,Usage,Production

Uses

FN-1501 is a potent inhibitor of FLT3 and CDK, with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 has anticancer activity.

in vivo

FN-1501 exhibits potent antitumor activity, and shows little cytotoxicity on normal lymphocyte cells, with LD50 of 185.67 mg/kg in ICR mice. FN-1501 (15. 30, or 40 mg/kg/d, i.v.) dose-dependently and significantly suppresses the growth of tumor in MV4-11-cell-inoculated-xenograft mice[1].

IC 50

Cdk4/cyclin D1: 0.85 nM (IC50); CDK6/cyclinD1: 1.96 nM (IC50); cdk2/cyclin A: 2.47 nM (IC50); FLT3: 0.28 nM (IC50)

References

[1] Wang Y, et al. Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia. J Med Chem. 2018 Feb 22;61(4):1499-1518. DOI:10.1021/acs.jmedchem.7b01261

FN-1501 Preparation Products And Raw materials

Raw materials

Preparation Products

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FN-1501 Suppliers

China 28 United States 2 Global 30
Mashilabs (Shanghai) Co.,Ltd.
Tel
19916721580
Fax
QQ：3154870176
Email
mafarm@126.com
Country
China
ProdList
4542
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai Yu Ben Biotechnology Co., Ltd.
Tel
021-61350663 15502154572
Fax
-
Email
1639466865@qq.com
Country
China
ProdList
498
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
18108052721
Email
2850505130@qq.com
Country
China
ProdList
5167
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Zhende Chemical Technology (Shanghai) Co., Ltd.
Tel
15601952568
Fax
3004479441
Email
sales4@myuchem.com
Country
China
ProdList
2994
Advantage
58

1429515-59-2, FN-1501Related Search:


  • 1H-Pyrazole-3-carboxamide, N-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-
  • 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide
  • FN-1501, 10 mM in DMSO
  • 1429515-59-2
  • C22H25N9O