SQ-31765

Product Name: SQ-31765
CAS No.: 138383-07-0
Chemical Name: SQ-31765
Synonyms: SQ31765,SQ 31765;3-(Acetyloxy)-1-(2-(dimethylamino)ethyl)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluromethyl)-2H-1-benzazepine-2-one;2H-1-Benzazepin-2-one, 3-(acetyloxy)-1-[2-(dimethylamino)ethyl]-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-, (3R,4S)-
CBNumber: CB74796692
Molecular Formula: C24H27F3N2O4
Formula Weight: 464.48
MOL File: 138383-07-0.mol

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SQ-31765 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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SQ-31765 Chemical Properties,Usage,Production

Uses

SQ-31765 is a benzazepine calcium channel blocker.

in vivo

SQ-31765 (SQ 31,765) can reduce the severity of ischemia in a manner which is independent of changes in myocardial blood flow or hemodynamic alterations. Anesthetized dogs are given saline (n=6), SQ-31765 (n=6; 0.2 mg/kg) or SQ 32,189 (n=6; 0.2 mg/kg) i.v. 10 min before ischemia. The effect on pacing-induced ST-segment elevation (pacing+left anterior descending coronary artery stenosis) and myocardial blood flow are determined. SQ-31765 reduces ST-elevation (P<0.05) compared to saline at 10, 40 and 70 min after infusion (5.9±1.4 and 12.0±1.4 mV, respectively, at 70 min). Left anterior descending coronary artery stenosis during atrial pacing resulted in a significant reduction in subendocardial flow in all groups before drug infusion (41±7, 44±7 and 35±9 mL/min/100 g for saline, SQ-31765 and SQ 32,189, respectively)^[1].

References

[1] Grover GJ, et al. Anti-ischemic and vasorelaxant effects of the new benzazepine calcium channel blocker SQ 31,765. J Pharmacol Exp Ther. 1989 Dec;251(3):1020-5. PMID:2481028

SQ-31765 Preparation Products And Raw materials

Raw materials

Preparation Products

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SQ-31765 Suppliers

China 6 United States 4 Global 10

TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Email: support@targetmol.com
Country: United States
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TargetMol Chemicals Inc.

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Email: marketing@targetmol.com
Country: United States
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MedChemExpress

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138383-07-0, SQ-31765Related Search:

2H-1-Benzazepin-2-one, 3-(acetyloxy)-1-[2-(dimethylamino)ethyl]-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-, (3R,4S)-

SQ31765,SQ 31765

3-(Acetyloxy)-1-(2-(dimethylamino)ethyl)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluromethyl)-2H-1-benzazepine-2-one

138383-07-0