Capzimin

Product Name: Capzimin
CAS No.: 2084868-04-0
Chemical Name: Capzimin
Synonyms: Capzimin dimer;Capzimin, 10 mM in DMSO;Capzimin dimer >=96% (HPLC);8,8'-Dithiobis[N-[2-(2-thiazolyl)ethyl]-3-quinolinecarboxamide;3-Quinolinecarboxamide, 8,8'-dithiobis[N-[2-(2-thiazolyl)ethyl]-;8,8'-Disulfanediylbis(N-(2-(thiazol-2-yl)ethyl)quinoline-3-carboxamide);8,8'-Disulfanediylbis(N-(2-(thiazol-2-yl)ethyl)quinoline-3-carboxamide)
CBNumber: CB74797028
Molecular Formula: C30H24N6O2S4
Formula Weight: 628.81
MOL File: 2084868-04-0.mol

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Capzimin Property

Boiling point:: 939.4±65.0 °C(Predicted)
Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:62.88(Max Conc. mg/mL);100.0(Max Conc. mM)
form: Solid
pka: 12.48±0.46(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D493825
Product name: 8,8''-Dithiobis[N-[2-(2-thiazolyl)ethyl]-3-quinolinecarboxamide]
Packaging: 1mg
Price: $115
Updated: 2021/12/16

TRC

Product number: D493825
Product name: 8,8''-Dithiobis[N-[2-(2-thiazolyl)ethyl]-3-quinolinecarboxamide]
Packaging: 5mg
Price: $480
Updated: 2021/12/16

ChemScene

Product number: CS-0042403
Product name: Capzimin
Purity: 99.32%
Packaging: 10mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0042403
Product name: Capzimin
Purity: 99.32%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0042403
Product name: Capzimin
Purity: 99.32%
Packaging: 25mg
Price: $1300
Updated: 2021/12/16

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Capzimin Chemical Properties,Usage,Production

Uses

8,8''-Dithiobis[N-[2-(2-thiazolyl)ethyl]-3-quinolinecarboxamide], is a novel Inhibitor of the Proteasome Subunit Rpn11.

Biological Activity

Capzimin can be used as a therapeutic for cancer treatment.', 'Capzimin dimer is the stable precursor form of capzimin. Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11, a proteasomal deubiquitinase th at is part of the proteosome 19S regulatory particle subunit th at removes the polyubiquitin chain from substrates in preparation for degradation. Capzimin was shown to have an IC50 value of 340 nM and have selectivity over related enzymes with 80-fold selectivity for Rpn11 over Csn5, ten-fold over AMSH and six-fold over BRCC36. It stabilized proteasome substrates th at would otherwise have been degraded, induced an unfolded protein response, and blocked the proliferation of cancer cells, including some th at had become resistant to bortezomib. Capzimin dimer will be quickly reduced to capzimin by glutathione in cell-based systems; DTT should be added to in vitro assays to reduce the disulfide.

storage

Store at -20°C

Capzimin Preparation Products And Raw materials

Raw materials

Preparation Products

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Capzimin Suppliers

China 26 United States 3 Global 29

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2084868-04-0, CapziminRelated Search:

3-Quinolinecarboxamide, 8,8'-dithiobis[N-[2-(2-thiazolyl)ethyl]-

Capzimin dimer >=96% (HPLC)

8,8'-Dithiobis[N-[2-(2-thiazolyl)ethyl]-3-quinolinecarboxamide

8,8'-Disulfanediylbis(N-(2-(thiazol-2-yl)ethyl)quinoline-3-carboxamide)

Capzimin dimer

Capzimin, 10 mM in DMSO

8,8'-Disulfanediylbis(N-(2-(thiazol-2-yl)ethyl)quinoline-3-carboxamide)

2084868-04-0

C30H24N6O2S4