ChemicalBook > CAS DataBase List > BMS-986165
BMS-986165
Uses- Product Name
- BMS-986165
- CAS No.
- 1609392-27-9
- Chemical Name
- BMS-986165
- Synonyms
- Deucravacitinib;6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl) phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide;Tyk2-IN-4;Deucravacitinb;BMS-986165 API;BMS-986165, >98% (HPLC);Deucravacitinib (TYK2-IN-4;Deucravacitinib(BMS986165);Deucravacitinib, 10 mM in DMSO;TYK2-IN-4;BMS986165;BMS-986165;BMS 986165
- CBNumber
- CB74808663
- Molecular Formula
- C20H22N8O3
- Formula Weight
- 422.45
- MOL File
- 1609392-27-9.mol
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BMS-986165 Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
- form
- A crystalline solid
- color
- Off-white to light yellow
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0065044
- Product name
- BMS-986165
- Purity
- 99.79%
- Packaging
- 10mg
- Price
- $350
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0065044
- Product name
- BMS-986165
- Purity
- 99.79%
- Packaging
- 50mg
- Price
- $850
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC12174
- Product name
- Deucravacitinib(BMS986165)
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1100
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC12174
- Product name
- Deucravacitinib(BMS986165)
- Purity
- >98%
- Packaging
- 1g
- Price
- $2200
- Updated
- 2021/12/16
Crysdot
- Product number
- CD31005021
- Product name
- 6-[(Cyclopropylcarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]amino}-N-(2H3)methyl-3-pyridazinecarboxamide
- Purity
- 98%
- Packaging
- 5mg
- Price
- $450
- Updated
- 2021/12/16
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BMS-986165 Chemical Properties,Usage,Production
Uses
BMS-986165 is a novel oral selective TYK2 inhibitor with a unique mechanism of action that is expected to provide a promising oral option to help patients effectively manage their psoriasis.
Uses
Deucravacitinib is a tyrosine kinase 2 inhibitor which can be useful in the treatment of systemic lupus erythematosus.
General Description
Deucravacitinib, a highly selective allosteric TYK2 inhibitor, received its first approval from the FDA in 2022 for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy protein and lipid kinases and pseudokinases with the exception of BMPR2 (IC50 = 193 nM) and JAK1 JH2 pseudokinase domain (IC50 = 1 nM). Despite its potent affinity for JAK1 JH2, deucravacitinib elicited low functional activity in a JAK1/JAK3-dependent IL-2 stimulated cellular assay. BMS-986202 displays >10,000-fold selectivity for TYK2 JH2 over a diverse panel of 273 kinases and pseudokinases that include JAK family members. Like deucravacitinib, its high binding affinity to JAK1 JH2 (IC50 = 7.8 nM) did not translate to functional activity in the cellular assay.
Pharmacokinetics
The crystalline free base form of deucravacitinib exhibited poor aqueous solubility (5.2 μg/mL), which was still acceptable for preclinical studies. It showed moderate half-lives of 4?5 h across species (mouse, dog, and monkey). Excellent exposures and high bioavailability (F > 85%) in mice, dogs, and monkeys were obtained from oral pharmacokinetic studies at a 10 mpk dose. Following oral administration of deucravacitinib, the major metabolite in human plasma was the cyclopropyl carboxamide hydrolytic cleavage product 4 (6-amino-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-methylpyridazine-3-carboxamide).
BMS-986165 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BMS-986165 manufacturers
hebei hongtan Biotechnology Co., Ltd
- Product
- BMS-986165 API 1609392-27-9
- Price
- US $100.00-80.00/KG
- Min. Order
- 1KG
- Purity
- 99.9%
- Supply Ability
- 500
- Release date
- 2024-03-18
hebei hongtan Biotechnology Co., Ltd
- Product
- Deucravacitinib 1609392-27-9
- Price
- US $20.00/g
- Min. Order
- 100g
- Purity
- 99.9%
- Supply Ability
- 1000kg
- Release date
- 2024-05-17
Cangzhou Kangrui Pharma Tech Co. Ltd.,
- Product
- Deucravacitinib 1609392-27-9
- Price
- US $0.00-0.00/g
- Min. Order
- 10g
- Purity
- 98%
- Supply Ability
- 5kgs
- Release date
- 2024-12-02