PZ-2891

Product Name: PZ-2891
CAS No.: 2170608-82-7
Chemical Name: PZ-2891
Synonyms: PZ-2891;PZ-2891 ，S0798;PZ-2891, 10 mM in DMSO;Inhibitor,PZ2891,inhibit,PZ-2891,PZ 2891;6-[4-[2-(4-propan-2-ylphenyl)acetyl]piperazin-1-yl]pyridazine-3-carbonitrile;3-Pyridazinecarbonitrile, 6-[4-[2-[4-(1-methylethyl)phenyl]acetyl]-1-piperazinyl]-
CBNumber: CB74812260
Molecular Formula: C20H23N5O
Formula Weight: 349.43
MOL File: 2170608-82-7.mol

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PZ-2891 Property

Boiling point:: 634.3±55.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:70.0(Max Conc. mg/mL);200.3(Max Conc. mM)
pka: 2.54±0.10(Predicted)
form: Solid
color: White to off-white

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Apolloscientific

Product number: BISN0079
Product name: PZ-2891
Purity: 98%
Packaging: 10mg
Price: $254
Updated: 2021/12/16

Apolloscientific

Product number: BISN0079
Product name: PZ-2891
Purity: 98%
Packaging: 50mg
Price: $653
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573231
Product name: PZ-2891
Purity: >98%
Packaging: 100mg
Price: $986
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573231
Product name: PZ-2891
Purity: >98%
Packaging: 250mg
Price: $1802
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573231
Product name: PZ-2891
Purity: >98%
Packaging: 1g
Price: $3580.2
Updated: 2021/12/16

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PZ-2891 Chemical Properties,Usage,Production

Uses

PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively[1].

References

[1] Sharma LK, et al. A therapeutic approach to pantothenate kinase associated neurodegeneration. Nat Commun. 2018 Oct 23;9(1):4399. DOI:10.1038/s41467-018-06703-2

PZ-2891 Preparation Products And Raw materials

Raw materials

Preparation Products

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PZ-2891 Suppliers

China 60 India 1 United States 4 Global 65

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
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ShangHai Angti Biotechnology Co., Ltd.

Tel: 13764913901
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Email: info@angtibio.com
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
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ShangHai Biochempartner Co.,Ltd

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Shanghai Chaolan Chemical Technology Center

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Shanghai SuperLan Chemcial Technique Centre

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Chuzhou KeMail Chemical Technology Co., Ltd

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Shanghai Bank Pharma Limited

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Fujian boshi pharmaceutical technology co. LTD

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Taizhou Crene Biotechnology Co. Ltd.

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Email: sales@pharm-intermediates.com
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2170608-82-7, PZ-2891Related Search:

PZ-2891

3-Pyridazinecarbonitrile, 6-[4-[2-[4-(1-methylethyl)phenyl]acetyl]-1-piperazinyl]-

Inhibitor,PZ2891,inhibit,PZ-2891,PZ 2891

PZ-2891, 10 mM in DMSO

PZ-2891 ，S0798

6-[4-[2-(4-propan-2-ylphenyl)acetyl]piperazin-1-yl]pyridazine-3-carbonitrile

2170608-82-7