Cetirizine-d8 (hydrochloride)
- Product Name
- Cetirizine-d8 (hydrochloride)
- CAS No.
- 2070015-04-0
- Chemical Name
- Cetirizine-d8 (hydrochloride)
- Synonyms
- Cetirizine-d8 DiHCl;Cetirizine-d8 (hydrochloride);[2H8]-Cetirizine Dihydrochloride
- CBNumber
- CB74814411
- Molecular Formula
- C21H18Cl2D8N2O3
- Formula Weight
- 433.398034224
- MOL File
- 2070015-04-0.mol
Cetirizine-d8 (hydrochloride) Property
- storage temp.
- Store at -20°C
- solubility
- Methanol: slightly soluble; Water: slightly soluble
- form
- A solid
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 26445
- Product name
- Cetirizine-d8 (hydrochloride)
- Packaging
- 500μg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 26445
- Product name
- Cetirizine-d8 (hydrochloride)
- Packaging
- 1mg
- Price
- $290
- Updated
- 2024/03/01
- Product number
- C281102
- Product name
- Cetirizine-d8Dihydrochloride
- Packaging
- 5mg
- Price
- $820
- Updated
- 2021/12/16
- Product number
- D4479
- Product name
- Cetirizine-d8DiHCl
- Packaging
- 5mg
- Price
- $1800
- Updated
- 2021/12/16
Cetirizine-d8 (hydrochloride) Chemical Properties,Usage,Production
Description
Cetirizine-d8 (hydrochloride) is intended for use as an internal standard for the quantification of cetirizine , (R)-cetirizine , and (S)-cetirizine by GC- or LC-MS. Cetirizine is a bioactive carboxylated metabolite of hydroxyzine that acts as a selective histamine H1 receptor antagonist (Ki = 10 nM). As a second generation antihistamine, it is non-sedating due to low lipophilicity, which prevents blood-brain barrier transit. Cetirizine is a racemic mixture composed of equal amounts of two enantiomers, (R)-cetirizine and (S)-cetirizine, with pharmacological activity residing primarily in the (R) isomer. Cetirizine inhibits eosinophil chemotaxis and leukotriene B4 (LTB4; ) release independent from H1 antagonism. It inhibits aerosol histamine-induced bronchospasm in guinea pigs (ED50 = 100 μg/kg, p.o.). Formulations containing cetirizine have been used in the treatment of allergic rhinitis and chronic urticaria.
Uses
A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.
Cetirizine-d8 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
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