GS5829,alobresib

Product Name: GS5829,alobresib
CAS No.: 1637771-14-2
Chemical Name: GS5829,alobresib
Synonyms: GS5829;GS5829,alobresib;Alobresib (GS-5829);Alobresib, 10 mM in DMSO;Inhibitor,GS5829,Alobresib,GS 5829,Epigenetic Reader Domain,inhibit;1H-Benzimidazole-7-methanol, 2-cyclopropyl-5-(3,5-dimethyl-4-isoxazolyl)-α,α-di-2-pyridinyl-
CBNumber: CB74815564
Molecular Formula: C26H23N5O2
Formula Weight: 437.5
MOL File: 1637771-14-2.mol

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GS5829,alobresib Property

Boiling point:: 718.9±60.0 °C(Predicted)
Density: 1.349±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:83.33(Max Conc. mg/mL);190.47(Max Conc. mM)
form: A solid
pka: 10.43±0.30(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0031496
Product name: Alobresib
Purity: 98.07%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-0031496
Product name: Alobresib
Purity: 98.07%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0031496
Product name: Alobresib
Purity: 98.07%
Packaging: 25mg
Price: $680
Updated: 2021/12/16

ChemScene

Product number: CS-0031496
Product name: Alobresib
Purity: 98.07%
Packaging: 50mg
Price: $1150
Updated: 2021/12/16

ChemScene

Product number: CS-0031496
Product name: Alobresib
Purity: 98.07%
Packaging: 100mg
Price: $1800
Updated: 2021/12/16

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GS5829,alobresib Chemical Properties,Usage,Production

Uses

Alobresib (GS-5829) is a BET bromodomain inhibitor, which represents a highly effective therapeutics agent against recurrent/chemotherapy resistant uterine serous carcinoma (USC) overexpressing c-Myc. Alobresib can be used in the metastatic castration-resistant prostate cancer (mCRPC) research[1][2].

in vivo

Alobresib (10 and 20 mg/kg; oral; twice-daily; for 28 days) impaires USC-ARK2 xenograft tumor growth in female CB17/lcrHsd-Prkd/scid mice. Alobresib exhibits a significantly slower rate of tumor growth in mice, compared with vehicle control and to mice undergoing daily treatment with JQ1 (50 mg/kg/day i.p.)^[1].
Alobresib (10 and 20 mg/kg; oral; twice-daily; for 28 days) is well tolerated with no clear impact on body weight compared with vehicle control^[1].

Animal Model:	Female CB17/lcrHsd-Prkd/scid mice (15-19 g) bearing USC-ARK2 tumors^[1]
Dosage:	10 and 20 mg/kg
Administration:	Oral; twice-daily; 28 days
Result:	Exhibited a significantly slower rate of tumor growth, compared with vehicle control and to mice undergoing daily treatment with JQ1 (50 mg/kg/day i.p.).

References

[1] Bonazzoli E, et al. Inhibition of BET Bromodomain Proteins with GS-5829 and GS-626510 in Uterine Serous Carcinoma, a Biologically Aggressive Variant of Endometrial Cancer. Clin Cancer Res. 2018 Oct 1;24(19):4845-4853. DOI:10.1158/1078-0432.CCR-18-0864
[2] Rahul Aggarwal, et al. Phase Ib Study of the BET Inhibitor GS-5829 as Monotherapy and Combined with Enzalutamide in Patients with Metastatic Castration-Resistant Prostate Cancer. Clin Cancer Res. 2022 Sep 15;28(18):3979-3989. DOI:10.1158/1078-0432.CCR-22-0175

GS5829,alobresib Preparation Products And Raw materials

Raw materials

Preparation Products

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GS5829,alobresib Suppliers

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1637771-14-2, GS5829,alobresibRelated Search:

GS5829,alobresib

Alobresib (GS-5829)

GS5829

1H-Benzimidazole-7-methanol, 2-cyclopropyl-5-(3,5-dimethyl-4-isoxazolyl)-α,α-di-2-pyridinyl-

Inhibitor,GS5829,Alobresib,GS 5829,Epigenetic Reader Domain,inhibit

Alobresib, 10 mM in DMSO

1637771-14-2