2,6-DICHLORO-3-NITROBENZOIC ACID
- Product Name
- 2,6-DICHLORO-3-NITROBENZOIC ACID
- CAS No.
- 55775-97-8
- Chemical Name
- 2,6-DICHLORO-3-NITROBENZOIC ACID
- Synonyms
- TIMTEC-BB SBB003247;RARECHEM AL BO 2381;2,6-DICHLORO-3-NITROBENZOIC ACID;Benzoic acid, 2,6-dichloro-3-nitro-;2,6-Dichloro-3-nitrobenzoic acid 98%
- CBNumber
- CB7484214
- Molecular Formula
- C7H3Cl2NO4
- Formula Weight
- 236.01
- MOL File
- 55775-97-8.mol
2,6-DICHLORO-3-NITROBENZOIC ACID Property
- Melting point:
- 152-158 °C(lit.)
- Boiling point:
- 374.4±42.0 °C(Predicted)
- Density
- 1.713±0.06 g/cm3(Predicted)
- Flash point:
- 152-158°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 0.76±0.29(Predicted)
- color
- White to Orange to Green
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 348899
- Product name
- 2,6-Dichloro-3-nitrobenzoic acid
- Purity
- 96%
- Packaging
- 5g
- Price
- $445
- Updated
- 2023/01/07
- Product number
- D5173
- Product name
- 2,6-Dichloro-3-nitrobenzoic Acid
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $92
- Updated
- 2025/07/31
- Product number
- D5173
- Product name
- 2,6-Dichloro-3-nitrobenzoic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $318
- Updated
- 2024/03/01
- Product number
- B426213
- Product name
- 2,6-Dichloro-3-nitrobenzoic Acid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- W6972
- Product name
- 2,6-Dichloro-3-nitrobenzoic Acid
- Packaging
- 1g
- Price
- $81
- Updated
- 2021/12/16
2,6-DICHLORO-3-NITROBENZOIC ACID Chemical Properties,Usage,Production
Uses
2,6-Dichloro-3-nitrobenzoic acid may be used in the preparation of 9-chloro-2-methoxy-6-nitro-5,10-dihydrobenzo[b][1,5]naphthyridin-10-one, required for the synthesis of potential DNA-binding antitumor agents. It may be used in the preparation of 2-(aminoalkyl)-5-nitropyrazolo [3,4,5-kl] acridines.
General Description
FT-IR and Raman spectra of 2, 6-dichloro-3-nitrobenzoic acid (DCNBA) have been investigated.
Synthesis
50-30-6
55775-97-8
Step a: Synthesis of 2,6-dichloro-3-nitrobenzoic acid 2,6-Dichlorobenzoic acid (10 g, 52 mmol) was added to a pre-stirred mixture of nitric acid (15 mL) and sulfuric acid (30 mL) and reacted at 55 °C for 30 min, followed by continued stirring at room temperature for 30 min. Upon completion of the reaction, the reaction mixture was slowly poured into ice-cold water (1 L) and the precipitated solid was filtered and dried to afford 2,6-dichloro-3-nitrobenzoic acid (9 g). The filtrate was extracted with ethyl acetate (2 x 200 mL), the organic layers were combined, dried over anhydrous sodium sulfate and concentrated to dryness to give the additional product (2 g). The total yield was 11 g in 88% yield. 1H NMR (400 MHz, MeOH-d4): δ 7.98 (d, J=8.8 Hz, 1H), 7.67 (d, J=8.8 Hz, 1H).
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 19, p. 6597 - 6611
[2] Patent: WO2012/160464, 2012, A1. Location in patent: Page/Page column 79
[3] Patent: US2014/155398, 2014, A1. Location in patent: Paragraph 0474
[4] Chemische Berichte, 1987, vol. 120, p. 803 - 810
[5] Chemische Berichte, 1937, vol. 70, p. 1526,1531
2,6-DICHLORO-3-NITROBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-DICHLORO-3-NITROBENZOIC ACID manufacturers
- Product
- 2,6-DICHLORO-3-NITROBENZOIC ACID 55775-97-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12