HYDROXYZINE HYDROCHLORIDE
- Product Name
- HYDROXYZINE HYDROCHLORIDE
- Chemical Name
- HYDROXYZINE HYDROCHLORIDE
- Synonyms
- HYDROXYZINE HYDROCHLORIDE
- CBNumber
- CB7484355
- Molecular Formula
- C21H28Cl2N2O2
- Formula Weight
- 411.37
- MOL File
- Mol file
HYDROXYZINE HYDROCHLORIDE Chemical Properties,Usage,Production
Originator
Atarax,UCB,France,1956
Manufacturing Process
A mixture of 0.1 mol of N-mono-1-p-chlorobenzohydrylpiperazine and 0.1 mol
of 1-chloro-2-(2-hydroxy-ethoxy)-ethane is heated for 3 hours to 150°C. The
mass is then taken up in 100 ml of benzene and 100 ml of a 10% aqueous
solution of NaOH; decanting takes place, and the benzene solution is washed
with water and the solvent is evaporated. Vacuum distilling of the residue
yields 1-p-chlorobenzohydryl-4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazine, BP
220°C/0.5 mm Hg.
The corresponding dihydrochloride is prepared by dissolving this base in about
twice its weight of alcohol, by treating it with excess of gaseous HCl and by
precipitating it with ether. The solvent is decanted and the residue, dissolved
in a minimum of alcohol, crystallizes on the addition of ether, MP 193°C.
Therapeutic Function
Tranquilizer
Clinical Use
Antihistamine:
Pruritus
Anxiety (short-term)
Drug interactions
Potentially hazardous interactions with other drugs
Analgesics: sedative effects possibly increased with
opioid analgesics.
Metabolism
Hydroxyzine is extensively metabolised. The formation of the major metabolite cetirizine, a carboxylic acid metabolite (approximately 45% of the oral dose), is mediated by alcohol dehydrogenase. This metabolite has significant peripheral H1-antagonist properties. The other metabolites identified include a N-dealkylated metabolite, and an O-dealkylated metabolite with a plasma half-life of 59 hours. These pathways are mediated principally by CYP3A4/5. Only 0.8% of the dose is excreted unchanged in urine. The major metabolite cetirizine is excreted mainly unchanged in urine (25% and 16 % of the hydroxyzine oral and IM dose, respectively).
HYDROXYZINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
HYDROXYZINE HYDROCHLORIDE Suppliers
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