AB 928

Product Name: AB 928
CAS No.: 2239273-34-6
Chemical Name: AB 928
Synonyms: AB 928);Etrumadenant;AB928 (AB-928;Etrumadenant (AB928);AB928, 10 mM in DMSO;Etrumadenant (AB928) ，S9608;AB928,inhibit,AB-928,AB 928,P1 receptor,Adenosine Receptor,Inhibitor;3-[2-Amino-6-[1-[[6-(2-hydroxypropan-2-yl)pyridin-2-yl]methyl]triazol-4-yl]pyrimidin-4-yl]-2-methylbenzonitrile;3-(2-amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile;Benzonitrile, 3-[2-amino-6-[1-[[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl]-1H-1,2,3-triazol-4-yl]-4-pyrimidinyl]-2-methyl-
CBNumber: CB74844430
Molecular Formula: C23H22N8O
Formula Weight: 426.47
MOL File: 2239273-34-6.mol

More

Less

AB 928 Property

Boiling point:: 723.4±70.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
form: A crystalline solid
pka: 13.33±0.29(Predicted)
color: Off-white to light yellow

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0105184
Product name: AB928
Purity: 99.30%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0105184
Product name: AB928
Purity: 99.30%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0105184
Product name: AB928
Purity: 99.30%
Packaging: 25mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0105184
Product name: AB928
Purity: 99.30%
Packaging: 50mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0105184
Product name: AB928
Purity: 99.30%
Packaging: 100mg
Price: $1450
Updated: 2021/12/16

More

Less

AB 928 Chemical Properties,Usage,Production

Uses

Etrumadenant (AB928) is an orally bioavailable, selective dual adenosine receptor (A2aR/A2bR) antagonist. Etrumadenant relieves adenosine-mediated immune suppression. Etrumadenant has immunomodulatory and antitumor activities[1][2].

in vivo

Concurrent treatment with Etrumadenant and chemotherapy results in significantly reduced tumor volume in vivo using AT3-OVA tumors; Similar results are observed for the combination of Etrumadenant and NSC 266046. AB928 is also capable of suppressing growth of B16-F10 tumors both as a single agent or in combination with α-PD-1 therapy. Etrumadenant increases the antitumor immune response leading to suppressed tumor growth and increased immune cell infiltration in mouse syngeneic tumors^[2].

References

[1] Seitz L, et al. Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers. Invest New Drugs. 2019 Aug;37(4):711-721. DOI:10.1007/s10637-018-0706-6
[2] Daniel DiRenzo, et al. AB928, a dual antagonist of the A2aR and A2bR adenosine receptors, relieves adenosine-mediated immune suppression [abstract].

AB 928 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

AB 928 Suppliers

China 76 United States 6 Global 82

ChemShuttle, Inc.

Tel: 0510-83588313-811 18800520310
Email: sales@chemshuttle.com
Country: China
ProdList: 2999
Advantage: 62

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Twochem Co.Ltd

Tel: 021-021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 304
Advantage: 55

ShangHai Angti Biotechnology Co., Ltd.

Tel: 13764913901
Fax: -
Email: info@angtibio.com
Country: China
ProdList: 4985
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1944
Advantage: 55

More

Less

View Lastest Price from AB 928 manufacturers

Zhejiang J&C Biological Technology Co.,Limited

Product: AB-928 2239273-34-6
Price: US $0.00/gram
Min. Order: 1gram
Purity: 99%
Supply Ability: 10kg
Release date: 2022-02-17

2239273-34-6, AB 928Related Search:

AB 928)

AB928 (AB-928

3-(2-amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile

Benzonitrile, 3-[2-amino-6-[1-[[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl]-1H-1,2,3-triazol-4-yl]-4-pyrimidinyl]-2-methyl-

Etrumadenant (AB928)

AB928,inhibit,AB-928,AB 928,P1 receptor,Adenosine Receptor,Inhibitor

3-[2-Amino-6-[1-[[6-(2-hydroxypropan-2-yl)pyridin-2-yl]methyl]triazol-4-yl]pyrimidin-4-yl]-2-methylbenzonitrile

AB928, 10 mM in DMSO

Etrumadenant

Etrumadenant (AB928) ，S9608

2239273-34-6

APIs