AB 928
- Product Name
- AB 928
- CAS No.
- 2239273-34-6
- Chemical Name
- AB 928
- Synonyms
- AB 928);Etrumadenant;AB928 (AB-928;Etrumadenant (AB928);AB928, 10 mM in DMSO;Etrumadenant (AB928) ，S9608;AB928,inhibit,AB-928,AB 928,P1 receptor,Adenosine Receptor,Inhibitor;3-[2-Amino-6-[1-[[6-(2-hydroxypropan-2-yl)pyridin-2-yl]methyl]triazol-4-yl]pyrimidin-4-yl]-2-methylbenzonitrile;3-(2-amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile;Benzonitrile, 3-[2-amino-6-[1-[[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl]-1H-1,2,3-triazol-4-yl]-4-pyrimidinyl]-2-methyl-
- CBNumber
- CB74844430
- Molecular Formula
- C23H22N8O
- Formula Weight
- 426.47
- MOL File
- 2239273-34-6.mol
AB 928 Property
- Boiling point:
- 723.4±70.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
- form
- A crystalline solid
- pka
- 13.33±0.29(Predicted)
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0105184
- Product name
- AB928
- Purity
- 99.30%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0105184
- Product name
- AB928
- Purity
- 99.30%
- Packaging
- 10mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0105184
- Product name
- AB928
- Purity
- 99.30%
- Packaging
- 25mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- CS-0105184
- Product name
- AB928
- Purity
- 99.30%
- Packaging
- 50mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- CS-0105184
- Product name
- AB928
- Purity
- 99.30%
- Packaging
- 100mg
- Price
- $1450
- Updated
- 2021/12/16
AB 928 Chemical Properties,Usage,Production
Uses
Etrumadenant (AB928) is an orally bioavailable, selective dual adenosine receptor (A2aR/A2bR) antagonist. Etrumadenant relieves adenosine-mediated immune suppression. Etrumadenant has immunomodulatory and antitumor activities[1][2].
in vivo
Concurrent treatment with Etrumadenant and chemotherapy results in significantly reduced tumor volume in vivo using AT3-OVA tumors; Similar results are observed for the combination of Etrumadenant and NSC 266046. AB928 is also capable of suppressing growth of B16-F10 tumors both as a single agent or in combination with α-PD-1 therapy. Etrumadenant increases the antitumor immune response leading to suppressed tumor growth and increased immune cell infiltration in mouse syngeneic tumors[2].
References
[1] Seitz L, et al. Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers. Invest New Drugs. 2019 Aug;37(4):711-721. DOI:10.1007/s10637-018-0706-6
[2] Daniel DiRenzo, et al. AB928, a dual antagonist of the A2aR and A2bR adenosine receptors, relieves adenosine-mediated immune suppression [abstract].
AB 928 Preparation Products And Raw materials
Raw materials
Preparation Products
AB 928 Suppliers
- Tel
- +1-781-999-5354; +17819995354
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- Country
- United States
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- 1-631-614-7828
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- United States
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- cayman@caymanchem.com
- Country
- United States
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View Lastest Price from AB 928 manufacturers
- Product
- AB-928 2239273-34-6
- Price
- US $0.00/gram
- Min. Order
- 1gram
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2022-02-17