ChemicalBook > CAS DataBase List > AER-271 (AER271)

AER-271 (AER271)

Product Name
AER-271 (AER271)
CAS No.
634913-39-6
Chemical Name
AER-271 (AER271)
Synonyms
AER-271;AER-271 (AER271);AER-271, 10 mM in DMSO;Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-(phosphonooxy)-;(2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenoxy)phosphonic acid;2-((3,5-Bis(trifluoromethyl)phenyl)carbamoyl)-4-chlorophenyl dihydrogen phosphate;Inhibitor,AER-271,AQP4,AER-270,stroke,inhibit,aquaporin-4,injury,AER 271,acute,AER271,CNS,ischemic
CBNumber
CB74844445
Molecular Formula
C15H9ClF6NO5P
Formula Weight
463.65
MOL File
634913-39-6.mol
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AER-271 (AER271) Property

Density 
1.692±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO:125.0(Max Conc. mg/mL);269.6(Max Conc. mM)
pka
0.97±0.50(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2737
Product name
AER-271
Purity
≥98% (HPLC)
Packaging
5MG
Price
$85
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2737
Product name
AER-271
Purity
≥98% (HPLC)
Packaging
25MG
Price
$345
Updated
2025/07/31
Biorbyt Ltd
Product number
orb611312
Product name
AER-271
Purity
>98%
Packaging
100mg
Price
$1133.9
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611312
Product name
AER-271
Purity
>98%
Packaging
250mg
Price
$1949.9
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611312
Product name
AER-271
Purity
>98%
Packaging
1g
Price
$3876
Updated
2021/12/16
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AER-271 (AER271) Chemical Properties,Usage,Production

Uses

AER-271, a phosphonate proagent derivative of AER-270, is an aquaporin-4 (AQP4) inhibitor for the research of acute ischemic stroke[1].

Biological Activity

AER-271 is a phosphonate precursor (prodrug) form of the selective aquaporin 4 (AQP4) inhibitor IMD-0354 (AER-270; hu/m/r IC50 = 420/390/210 nM using respective CHO AQP4 transfectants) with >5000-fold enhanced solubility. AER-271 is rapidly converted to AER-270 in vivo (plasma AER-270 Cmax = 500 ng/mL or 1.75 μM, 20 min post 10 mg AER-271/kg i.p.; C57BL/6 mice) and exhibits therapeutic efficacy in rodent models of brain damage by cardiac arrest or ischemic stroke (5-10 mg/kg ip. & 0.08 mg/h sc. in mice; 1-10 mg/kg iv. in rats).

in vivo

AER-271 is converted in vivo to AER-270 by endogenous phosphatases. AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest[1].
AER-271 reduces cerebral edema and improves neurological outcomes in rodent ischemic stroke models. Mice treated with AER-271 (5 mg/kg; i.p. injection) show improved outcomes and reduced cerebral edema in a model of ischemic stroke[2].

Animal Model:Male mice (C57BL/6J, 8-12?week-old, 25-30?g)[2]
Dosage:5?mg/kg
Administration:Treated by i.p. injection
Result:Had better outcomes with an average neurological score of 0.89±0.31 compared with control mice receiving vehicle had an average neurological score of 2.50±0.62.

References

[1] Wallisch JS, et al. The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest. Pediatr Res. 2019 Mar;85(4):511-517. DOI:10.1038/s41390-018-0215-5
[2] Farr GW, et al. Functionalized Phenylbenzamides Inhibit Aquaporin-4 Reducing Cerebral Edema and Improving Outcome in Two Models of CNS Injury. Neuroscience. 2019 Apr 15;404:484-498. DOI:10.1016/j.neuroscience.2019.01.034

AER-271 (AER271) Preparation Products And Raw materials

Raw materials

Preparation Products

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AER-271 (AER271) Suppliers

China 37 India 1 United States 4 Global 42

634913-39-6, AER-271 (AER271)Related Search:


  • AER-271 (AER271)
  • AER-271
  • Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-(phosphonooxy)-
  • Inhibitor,AER-271,AQP4,AER-270,stroke,inhibit,aquaporin-4,injury,AER 271,acute,AER271,CNS,ischemic
  • 2-((3,5-Bis(trifluoromethyl)phenyl)carbamoyl)-4-chlorophenyl dihydrogen phosphate
  • (2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenoxy)phosphonic acid
  • AER-271, 10 mM in DMSO
  • 634913-39-6
  • C15H9ClF6NO5P