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CLK inhibitor T3 (T3)

Product Name
CLK inhibitor T3 (T3)
CAS No.
2109805-56-1
Chemical Name
CLK inhibitor T3 (T3)
Synonyms
T3-CLK;CLK-IN-T3;CLK inhibitor T3 (T3);CLK-IN-T3, 10 mM in DMSO;T3 CLK New;4-[1,1-Dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide;Benzamide, 4-[1,1-dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]-;CDC-like,Dual specificity tyrosine phosphorylation regulated kinase,inhibit,Dual specificity tyrosine regulated kinase,stable,anti-cancer,DYRK,CLK,kinase,CDK,CLK-IN-T-3,CLKINT3,DYRK1A,Inhibitor,activity,CLK IN T3,DYRK1B,Cyclin dependent kinase
CBNumber
CB74844652
Molecular Formula
C28H30N6O2
Formula Weight
482.58
MOL File
2109805-56-1.mol
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CLK inhibitor T3 (T3) Property

Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: 2mg/mL, clear (warmed)
form 
Solid
pka
4.70±0.46(Predicted)
color 
Off-white to light yellow
InChIKey
IEFFSHLHNYVSEF-UHFFFAOYSA-N
SMILES
C(NC1=CN2C(=N1)C=CC(C1C=CN=CC=1)=C2)(=O)C1=CC=C(C(C)(C)C(N2CCN(C)CC2)=O)C=C1
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0087015
Product name
CLK-IN-T3
Purity
98.40%
Packaging
5mg
Price
$155
Updated
2021/12/16
ChemScene
Product number
CS-0087015
Product name
CLK-IN-T3
Purity
98.40%
Packaging
10mg
Price
$265
Updated
2021/12/16
ChemScene
Product number
CS-0087015
Product name
CLK-IN-T3
Purity
98.40%
Packaging
25mg
Price
$560
Updated
2021/12/16
ChemScene
Product number
CS-0087015
Product name
CLK-IN-T3
Purity
98.40%
Packaging
50mg
Price
$950
Updated
2021/12/16
ChemScene
Product number
CS-0087015
Product name
CLK-IN-T3
Purity
98.40%
Packaging
100mg
Price
$1650
Updated
2021/12/16
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CLK inhibitor T3 (T3) Chemical Properties,Usage,Production

Uses

CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC50s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity[1].

Biological Activity

T3-CLK (T3) is a cell permeable, highly potent and selective cell-base stable inhibitor of CDC-like kinase (CLK) th at exhibits dose-dependent alternative splicing effects in HCT116 colorectal cancer cells. T3-CLK increases conjoined gene (CG) transcription.

IC 50

CLK1: 0.67 nM (IC50); CLK2: 15 nM (IC50); CLK3: 110 nM (IC50); DYRK1A: 260 nM (IC50); DYRK1B: 230 nM (IC50)

References

[1] Funnell T, et al. CLK-dependent exon recognition and conjoined gene formation revealed with a novel smallmolecule inhibitor. Nat Commun. 2017 Feb 23;8(1):7. DOI:10.1038/s41467-016-0008-7

CLK inhibitor T3 (T3) Preparation Products And Raw materials

Raw materials

Preparation Products

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CLK inhibitor T3 (T3) Suppliers

China 33 United States 4 Global 37
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070 13913916777;
Fax
+86-25-83453306
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info@chemlin.com.cn
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China
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BOC Sciences
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1-631-485-4226; 16314854226
Email
info@bocsci.com
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United States
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
Fax
021-65675885
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info@efebio.com
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China
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
Fax
21-5161 9052
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Sales@ATKchemical.com
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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InvivoChem
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+1-708-310-1919 +1-13798911105
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708-557-7486
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sales@invivochem.cn
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United States
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd
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15317229551
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QQ:3607245178
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15151849396@163.com
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China
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989
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ShangHai ChuanQian Chemcial Technique Centre
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15869524721
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3525679403@qq.com
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China
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2109805-56-1, CLK inhibitor T3 (T3)Related Search:


  • CLK inhibitor T3 (T3)
  • CLK-IN-T3
  • Benzamide, 4-[1,1-dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]-
  • T3-CLK
  • CDC-like,Dual specificity tyrosine phosphorylation regulated kinase,inhibit,Dual specificity tyrosine regulated kinase,stable,anti-cancer,DYRK,CLK,kinase,CDK,CLK-IN-T-3,CLKINT3,DYRK1A,Inhibitor,activity,CLK IN T3,DYRK1B,Cyclin dependent kinase
  • T3 CLK New
  • CLK-IN-T3, 10 mM in DMSO
  • 4-[1,1-Dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide
  • 2109805-56-1
  • C28H30N6O2