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CSF1R-IN-1

Product Name
CSF1R-IN-1
CAS No.
2095849-04-8
Chemical Name
CSF1R-IN-1
Synonyms
CSF1R-IN-1;CSF1R-IN-22;CSF1R-IN-1, 10 mM in DMSO;5-(1-Methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide;5-(1-Methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide , CSF1R-IN-1;3-Pyridinecarboxamide, 5-(1-methyl-1H-pyrazol-4-yl)-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]-;Inhibitor,inhibit,c-Fms,CSF1R IN 1,colony stimulating factor 1 receptor,CSF1RIN1,CSF-1R-IN-1,CSF1R,CSF-1R,CSF-1 receptor
CBNumber
CB74844672
Molecular Formula
C25H20F3N5O2
Formula Weight
479.45
MOL File
2095849-04-8.mol
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CSF1R-IN-1 Property

Boiling point:
528.3±50.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
11.58±0.70(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0021878
Product name
CSF1R-IN-1
Purity
98.75%
Packaging
5mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0021878
Product name
CSF1R-IN-1
Purity
98.75%
Packaging
10mg
Price
$480
Updated
2021/12/16
ChemScene
Product number
CS-0021878
Product name
CSF1R-IN-1
Purity
98.75%
Packaging
25mg
Price
$950
Updated
2021/12/16
ChemScene
Product number
CS-0021878
Product name
CSF1R-IN-1
Purity
98.75%
Packaging
50mg
Price
$1450
Updated
2021/12/16
ChemScene
Product number
CS-0021878
Product name
CSF1R-IN-1
Purity
98.75%
Packaging
100mg
Price
$2250
Updated
2021/12/16
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CSF1R-IN-1 Chemical Properties,Usage,Production

Uses

CSF1R-IN-1 is a CSF1R inhibitor with an with an IC50 of 0.5 nM.

in vivo

CSF1R-IN-1 has favorable pharmacokinetics when dosed orally to mice. It appears suitable for in vivo pharmacology testing in the appropriate preclinical tumor model to demonstrate proof of concept.[1].

Animal Model:Male CD-1 mice, 25-35 grams (8-11 weeks old)[1]
Dosage:2 mg/kg IV or 10 mg/kg orally (Per Os)
Administration:i.v. or oral
Result:I.V.: Cmax=3.55, T1/2=0.87 P.O.: Cmax=4.6, T1/2=1.8, Bioavailability=64%

References

[1] Ramachandran SA, et al. Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors. Bioorg Med Chem Lett. 2017 May 15;27(10):2153-2160. DOI:10.1016/j.bmcl.2017.03.064

CSF1R-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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CSF1R-IN-1 Suppliers

China 28 United States 5 Global 33
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
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56
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4800
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
10408
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Jinan Jiuli Biotechnology Co. , Ltd.
Tel
15865264761
Email
486064515@qq.com
Country
China
ProdList
4858
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
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58
Hefei Mokai Pharmaceutical Technology Co., Ltd
Tel
18130062233
Email
3362556465@qq.com
Country
China
ProdList
8100
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58

2095849-04-8, CSF1R-IN-1Related Search:


  • CSF1R-IN-1
  • CSF1R-IN-22
  • 3-Pyridinecarboxamide, 5-(1-methyl-1H-pyrazol-4-yl)-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]-
  • 5-(1-Methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide
  • Inhibitor,inhibit,c-Fms,CSF1R IN 1,colony stimulating factor 1 receptor,CSF1RIN1,CSF-1R-IN-1,CSF1R,CSF-1R,CSF-1 receptor
  • CSF1R-IN-1, 10 mM in DMSO
  • 5-(1-Methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide , CSF1R-IN-1
  • 2095849-04-8