GO 289)

Product Name: GO 289)
CAS No.: 694522-87-7
Chemical Name: GO 289)
Synonyms: GO 289);(E/Z） O289;(EZ)-GO289;GO289 (GO-289;(E/Z)-GO289, 10 mM in DMSO;5-Bromo-2-methoxy-4-(((3-(methylthio)-5-phenyl-4H-1,2,4-triazol-4-yl)imino)methyl)phenol;Phenol, 5-bromo-2-methoxy-4-[[[3-(methylthio)-5-phenyl-4H-1,2,4-triazol-4-yl]imino]methyl]-;Inhibitor,cancer,(E/Z)GO289,circadian,(E/Z)-GO-289,cell,clock,rhythms,growth,(E/Z) GO289,phosphorylation,(E/Z)-GO289,Casein Kinase,inhibit
CBNumber: CB74844814
Molecular Formula: C17H15BrN4O2S
Formula Weight: 419.3
MOL File: 694522-87-7.mol

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GO 289) Property

Boiling point:: 618.0±65.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 2mg/mL, clear
pka: 7.53±0.40(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3447
Product name: GO289
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $132
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3447
Product name: GO289
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $426
Updated: 2024/03/01

TRC

Product number: G767505
Product name: GO289
Packaging: 50mg
Price: $765
Updated: 2021/12/16

TRC

Product number: G767505
Product name: GO289
Packaging: 100mg
Price: $1320
Updated: 2021/12/16

TRC

Product number: G767505
Product name: GO289
Packaging: 10mg
Price: $165
Updated: 2021/12/16

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GO 289) Chemical Properties,Usage,Production

Uses

GO289, is a new potent and highly selective CK2 inhibitor, which strongly lengthens circadian period. It inhibits multiple phsphorylation sites on clock proteins, including PER2 S693. GO289, also exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function.

Biological Activity

GO289 is a highly potent and selective casein kinase CK2 (CKII) inhibitor (IC50 = 7 nM/CK2, 13 μM/PIM2, >50 μM/CLK2; <50% inhibition of CK1α/δ/γ and 56 other kinases at 5 μM) th at targets CK2-specific residues (CK2α V66, M163, and H160) with more overall interactions at the CK2 ATP-binding pocket than TBB, DM at & CX-4945. GO289 selectively inhibits cellular CK1 substrates phosphorylation (0.8-8 μM; HEK293T, U2OS), including clock proteins PER2, CRY1, CLOCK & BMAL1, and displays circadian period-lengthening (Bmal1-dLuc USOS EC50 = 3.3 μM) as well as growth inhibitory potency in CK2-dependent human renal cell carcinoma (RCC) cultures.

GO 289) Preparation Products And Raw materials

Raw materials

Preparation Products

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GO 289) Suppliers

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694522-87-7, GO 289)Related Search:

GO 289)

GO289 (GO-289

Phenol, 5-bromo-2-methoxy-4-[[[3-(methylthio)-5-phenyl-4H-1,2,4-triazol-4-yl]imino]methyl]-

(EZ)-GO289

5-Bromo-2-methoxy-4-(((3-(methylthio)-5-phenyl-4H-1,2,4-triazol-4-yl)imino)methyl)phenol

Inhibitor,cancer,(E/Z)GO289,circadian,(E/Z)-GO-289,cell,clock,rhythms,growth,(E/Z) GO289,phosphorylation,(E/Z)-GO289,Casein Kinase,inhibit

(E/Z） O289

(E/Z)-GO289, 10 mM in DMSO

694522-87-7