NVS-ZP7-4
- Product Name
- NVS-ZP7-4
- CAS No.
- 2349367-89-9
- Chemical Name
- NVS-ZP7-4
- Synonyms
- NVS-ZP7-4;NVS-ZP7-4, 10 mM in DMSO;Inhibitor,NVS-ZP-7-4,inhibit,NVSZP74,NVS ZP7 4;(S)-1-(2-((6-Fluorobenzo[d]thiazol-2-yl)amino)-3-phenylpropyl)-1'H-spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one;Spiro[piperidine-4,4'(1'H)-quinazolin]-2'(3'H)-one, 1-[(2S)-2-[(6-fluoro-2-benzothiazolyl)amino]-3-phenylpropyl]-
- CBNumber
- CB74845033
- Molecular Formula
- C28H28FN5OS
- Formula Weight
- 501.62
- MOL File
- 2349367-89-9.mol
NVS-ZP7-4 Property
- storage temp.
- -20°C, protect from light
- solubility
- DMSO: soluble; Ethanol: soluble
- form
- A solid
- color
- Light yellow to yellow
- InChIKey
- FZOFDZMKSAUTHT-NRFANRHFSA-N
- SMILES
- Fc1cc2[s]c(nc2cc1)N[C@H](CN4CCC5(NC(=O)Nc6c5cccc6)CC4)Cc3ccccc3
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
N-Bromosuccinimide Price
- Product number
- orb611293
- Product name
- NVS-ZP7-4
- Purity
- >98%
- Packaging
- 100mg
- Price
- $1208.7
- Updated
- 2021/12/16
- Product number
- orb611293
- Product name
- NVS-ZP7-4
- Purity
- >98%
- Packaging
- 250mg
- Price
- $2245.7
- Updated
- 2021/12/16
- Product number
- orb611293
- Product name
- NVS-ZP7-4
- Purity
- >98%
- Packaging
- 1g
- Price
- $4469.3
- Updated
- 2021/12/16
NVS-ZP7-4 Chemical Properties,Usage,Production
Uses
NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7) and indicates ER zinc levels. ZIP7 is an active molecular node in the Notch pathway and mediates ferroptosis. NVS-ZP7-4 induces ER stress and exerts a certain ferroptosis-inhibiting effect, reduces Erastin (HY-15763)-induced cell death[1][2].
Biological Activity
NVS-ZP7-4 is a potent inhibitor of the Notch signaling pathway th at induces endoplasmic reticulum (ER) stress and induces apoptosis in T-ALL cell lines. NVS-ZP7-4 is a potent and selective inhibitor of SLC39A7 (ZIP7) zinc transporter th at increases ER zinc levels.
References
[1] Nolin E, et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15(2):179-188. DOI:10.1038/s41589-018-0200-7
[2] Chen PH, et al. Zinc transporter ZIP7 is a novel determinant of ferroptosis. Cell Death Dis. 2021 Feb 19;12(2):198. DOI:10.1038/s41419-021-03482-5
NVS-ZP7-4 Preparation Products And Raw materials
Raw materials
Preparation Products
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