Desethyl Chloroquine-d5 DiHCl

Product Name: Desethyl Chloroquine-d5 DiHCl
CAS No.: 1261392-69-1
Chemical Name: Desethyl Chloroquine-d5 DiHCl
Synonyms: Desethylchloroquine D5;[2H5]-Desethylchloroquine;Desethyl Chloroquine-d5 DiHCl;HydroxychloroquineEPImpurityD-d5
CBNumber: CB74849213
Molecular Formula: C16H22ClN3
Formula Weight: 291.82
MOL File: 1261392-69-1.mol

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Hazard and Precautionary Statements (GHS)

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Desethyl Chloroquine-d5 DiHCl Chemical Properties,Usage,Production

Uses

Desethyl chloroquine-d5 is deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].

IC 50

Plasmodium

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100. PMID:2547293
[3] Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43. DOI:10.4049/jimmunol.1303276
[4] Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3(2):159-74. DOI:10.3233/JHD-130081

Desethyl Chloroquine-d5 DiHCl Preparation Products And Raw materials

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1261392-69-1, Desethyl Chloroquine-d5 DiHClRelated Search:

Desethyl Chloroquine-d5 DiHCl

[2H5]-Desethylchloroquine

Desethylchloroquine D5

HydroxychloroquineEPImpurityD-d5

1261392-69-1