Azidoethyl-SS-propionic acid

Product Name: Azidoethyl-SS-propionic acid
CAS No.: 2228857-32-5
Chemical Name: Azidoethyl-SS-propionic acid
Synonyms: Azido-PEG1-S-S-acid;Azidoethyl-SS-propionic acid
CBNumber: CB74849536
Molecular Formula: C5H9N3O2S2
Formula Weight: 207.27
MOL File: 2228857-32-5.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24063
Product name: Azidoethyl-SS-propionicacid
Purity: 95%
Packaging: 100mg
Price: $350
Updated: 2021/12/16

BroadPharm

Product number: BP-24063
Product name: Azidoethyl-SS-propionicacid
Purity: 95%
Packaging: 250mg
Price: $650
Updated: 2021/12/16

BroadPharm

Product number: BP-24063
Product name: Azidoethyl-SS-propionicacid
Purity: 95%
Packaging: 500mg
Price: $995
Updated: 2021/12/16

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Azidoethyl-SS-propionic acid Chemical Properties,Usage,Production

Description

Azidoethyl-SS-propionic acid is a Click Chemistry-ready crosslinker. The azide group enables Click Chemistry. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The disulfide bond can be cleaved by Dithiothreitol (DTT) reagent

Uses

Azidoethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azidoethyl-SS-propionic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Disulfide Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Azidoethyl-SS-propionic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Azidoethyl-SS-propionic acid Suppliers

China 17 United States 4 Global 21

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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2228857-32-5, Azidoethyl-SS-propionic acidRelated Search:

Azidoethyl-SS-propionic acid

Azido-PEG1-S-S-acid

2228857-32-5