Crisaborole Impurity

Product Name
Crisaborole Impurity
CAS No.
906673-42-5
Chemical Name
Crisaborole Impurity
Synonyms
Crisaborole Impurity 26;Crisaborole intermediate;5-(4-cyanophenoxy)-2-hydroxybenzoic acid;4-(3-formyl-4-hydroxyphenoxy)benzonitrile;4-(2-bromo-5-(hydroxymethyl)phenoxy)benzonitrile;4-(2,4-dibromo-5-(hydroxymethyl)phenoxy)benzonitrile;4-(4-(4-bromo-3-formylphenoxy)-3-formylphenoxy)benzonitrile;3-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]Benzonitrile;3-[(1-Hydroxy-1 3-dihydro-2 1-benzoxaborole-5-yl)oxy]benzonitrile;Benzonitrile, 3-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]-
CBNumber
CB74868636
Molecular Formula
C14H10BNO3
Formula Weight
251.05
MOL File
906673-42-5.mol
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Crisaborole Impurity Property

Melting point:
180-183°C
Boiling point:
411.1±55.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly)
pka
7.04±0.20(Predicted)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D453020
Product name
3-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile
Packaging
50mg
Price
$4400
Updated
2021/12/16
TRC
Product number
D453020
Product name
3-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile
Packaging
100mg
Price
$8250
Updated
2021/12/16
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Crisaborole Impurity Chemical Properties,Usage,Production

Uses

5-(4-Cyanophenoxy)-2-hydroxybenzoic Acid is an impurity of Crisaborole(H947928). Crisaborole exhibits inhibitory activity against PDE4 and cytokine release.

Crisaborole Impurity Preparation Products And Raw materials

Raw materials

Preparation Products

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Crisaborole Impurity Suppliers

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906673-42-5, Crisaborole ImpurityRelated Search:


  • 3-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]Benzonitrile
  • Crisaborole intermediate
  • 5-(4-cyanophenoxy)-2-hydroxybenzoic acid
  • 4-(3-formyl-4-hydroxyphenoxy)benzonitrile
  • 4-((2,2'-diformyl-4'-(4-isocyanophenoxy)-[1,1'-biphenyl]-4-yl)oxy)benzonitrile
  • 4-(3-formyl-4-(3-formyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)phenoxy)benzonitrile
  • 4-(3-(hydroxymethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)benzonitrile
  • 4-(2-bromo-5-(hydroxymethyl)phenoxy)benzonitrile
  • 4-(2,4-dibromo-5-(hydroxymethyl)phenoxy)benzonitrile
  • 4-(4-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)-3-(hydroxymethyl)phenoxy)benzonitrile
  • 4-(4-(4-bromo-3-(hydroxymethyl)phenoxy)-3-(hydroxymethyl)phenoxy)benzonitrile
  • 4-(4-(4-bromo-3-formylphenoxy)-3-formylphenoxy)benzonitrile
  • Benzonitrile, 3-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]-
  • Crisaborole Impurity 26
  • 3-[(1-Hydroxy-1 3-dihydro-2 1-benzoxaborole-5-yl)oxy]benzonitrile
  • 906673-42-5
  • GYL