ChemicalBook > CAS DataBase List > 4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide

4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide

Product Name
4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide
CAS No.
1884640-99-6
Chemical Name
4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide
Synonyms
NI-42 >=98% (HPLC);NI-42, 10 mM in DMSO;BRPF1 inhibitor NI-42;NI-42,Inhibitor,inhibit,NI 42,Epigenetic Reader Domain,NI42;4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide;4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide;Benzenesulfonamide, 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-
CBNumber
CB74902796
Molecular Formula
C18H15N3O3S
Formula Weight
353.39
MOL File
1884640-99-6.mol
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4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide Property

Boiling point:
554.6±60.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form 
A crystalline solid
pka
8.05±0.20(Predicted)
color 
white to beige
InChI
InChI=1S/C18H15N3O3S/c1-12-9-14-10-15(5-8-17(14)21(2)18(12)22)20-25(23,24)16-6-3-13(11-19)4-7-16/h3-10,20H,1-2H3
InChIKey
BMVCSXFOQPYKKC-UHFFFAOYSA-N
SMILES
C1(S(NC2C=CC3=C(C=2)C=C(C)C(=O)N3C)(=O)=O)=CC=C(C#N)C=C1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28293
Product name
NI-42
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
28293
Product name
NI-42
Packaging
25mg
Price
$381
Updated
2024/03/01
Cayman Chemical
Product number
28293
Product name
NI-42
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
28293
Product name
NI-42
Packaging
10mg
Price
$169
Updated
2024/03/01
TRC
Product number
N900610
Product name
NI42
Packaging
1mg
Price
$90
Updated
2021/12/16
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4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide Chemical Properties,Usage,Production

Description

NI-42 is an inhibitor of the bromodomain and PHD finger-containing 1 (BRPF1) bromodomain (IC50 = 7.9 nM). It is selective for BRPF1 over BRPF2/BRD1, BRPF3, BRD9, and BRD4/BD1 (IC50s = 48, 260, 310, and 4,500 nM, respectively). NI-42 inhibits the growth of OCI-AML2, Nomo-1, THP-1, KG-1, and MV-4-11 acute myeloid leukemia (AML) cells (GI50s = 1.3, 4.6, 5.7, 7, and 9.9 μM, respectively) and a variety of non-AML cells (GI50s = 1-10 μM). It also inhibits the growth of DMS114 lung, HRA-19 colon, and RERF-LC-Sq1 lung cancer cells (GI50s = 16.6, 15.6, and 17.1 μM, respectively) but not NCI H1703 lung cancer cells (GI50 = >30 μM).

Uses

NI-42 is a new chemical probe for the BRPFs (bromodomain and PHD finger-containing) suitable for cellular and invivo studies to explore the fundamental biology of these proteins.

IC 50

BRPF1: 7.9 nM (IC50); BRPF2: 48 nM (IC50); BRPF3: 260 nM (IC50); BRPF1: 40 nM (Kd); BRPF2: 210 nM (Kd); BRPF3: 940 nM (Kd); BRD4 (BD1): 4500 nM (IC50); BRD7: 82 nM (IC50); BRD9: 310 nM (IC50); BRD9: 1130 nM (Kd)

References

[1] NIALL IGOE. Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies[J]. Journal of Medicinal Chemistry, 2017, 60 2: 668-680. DOI: 10.1021/acs.jmedchem.6b01583
[2] NIALL IGOE. Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins[J]. Journal of Medicinal Chemistry, 2017, 60 16: 6998-7011. DOI: 10.1021/acs.jmedchem.7b00611

4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide Suppliers

China 43 United Kingdom 1 United States 3 Global 47
Anqing YanZhi Pharma Discovery Co.,Ltd.
Tel
18055651951
Email
2272561977@qq.com
Country
China
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435
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Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
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58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
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55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
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58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
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3008007409@qq.com
Country
China
ProdList
71826
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60
ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
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62
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1944
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55
Shanghai Yu Ben Biotechnology Co., Ltd.
Tel
021-61350663 15502154572
Fax
-
Email
1639466865@qq.com
Country
China
ProdList
498
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58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
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32435
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58

1884640-99-6, 4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamideRelated Search:


  • 4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide
  • BRPF1 inhibitor NI-42
  • NI-42 >=98% (HPLC)
  • NI-42,Inhibitor,inhibit,NI 42,Epigenetic Reader Domain,NI42
  • Benzenesulfonamide, 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-
  • 4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide
  • NI-42, 10 mM in DMSO
  • 1884640-99-6