INDOMETHACIN N-OCTYL AMIDE

Product Name: INDOMETHACIN N-OCTYL AMIDE
CAS No.: 282728-65-8
Chemical Name: INDOMETHACIN N-OCTYL AMIDE
Synonyms: INDOMETHACIN N-OCTYL AMIDE;N-OCTYL-1-(4-CHLOROBENZOYL)-5-METHOXY-1H-INDOLE-3-ACETAMIDE;2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-octylacetamide;1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-octyl-
CBNumber: CB7490411
Molecular Formula: C27H33ClN2O3
Formula Weight: 469.02
MOL File: Mol file

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INDOMETHACIN N-OCTYL AMIDE Property

storage temp.: Store at -20°C
solubility: ≤2mg/ml in ethanol;27mg/ml in dimethyl formamide
form: crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 70273
Product name: Indomethacin N-octyl amide
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 70273
Product name: Indomethacin N-octyl amide
Purity: ≥98%
Packaging: 5mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 70273
Product name: Indomethacin N-octyl amide
Purity: ≥98%
Packaging: 10mg
Price: $186
Updated: 2024/03/01

Cayman Chemical

Product number: 70273
Product name: Indomethacin N-octyl amide
Purity: ≥98%
Packaging: 50mg
Price: $807
Updated: 2024/03/01

ApexBio Technology

Product number: C5591
Product name: IndomethacinN-octylamide
Packaging: 50mg
Price: $922
Updated: 2021/12/16

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INDOMETHACIN N-OCTYL AMIDE Chemical Properties,Usage,Production

Biological Activity

indomethacin n-octyl amide is a potent and non-selective inhibitor of both cox-1 and cox-2 [1].cyclooxygenase (cox) is the key enzyme required for the conversion of arachidonic acid to prostaglandins. cyclooxygenase enzymes have been involved in diverse physiological situations and disease processes ranging from inflammation to cancer. until now, two cyclooxygenase isoforms have been identified, cox-1 and cox-2. the cox-1 enzyme is produced constitutively (i.e., gastric mucosa) and cox-2 is inducible (i.e., sites of inflammation) [2].indomethacin is a potent but non-selective inhibitor of both cox-1 and cox-2. indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivitized as an ester or amide. conversion of indomethacin into ester and amide derivatives provides a facile strategy for generating highly selective cox-2 inhibitors. indomethacin n-octyl amide inhibited the activity of ovine cox-1 and human recombinant cox-2 with the ic50 values of 66 μm and 40 nm, respectively. while the ic50 of indomethacin for the inhibition of cox-1 and cox-2 were 0.67 μm and 0.05 μm, respectively [1].

References

[1] kalgutkar a s, marnett a b, crews b c, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors[j]. journal of medicinal chemistry, 2000, 43(15): 2860-2870.
[2] dubois r n, abramson s b, crofford l, et al. cyclooxygenase in biology and disease[j]. the faseb journal, 1998, 12(12): 1063-1073.

INDOMETHACIN N-OCTYL AMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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INDOMETHACIN N-OCTYL AMIDE Suppliers

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282728-65-8, INDOMETHACIN N-OCTYL AMIDERelated Search:

N-OCTYL-1-(4-CHLOROBENZOYL)-5-METHOXY-1H-INDOLE-3-ACETAMIDE

2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-octylacetamide

INDOMETHACIN N-OCTYL AMIDE

1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-octyl-

282728-65-8

C27H33ClN2O3