2-((1H-benzo[d]imidazol-1-yl)methyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
- Product Name
- 2-((1H-benzo[d]imidazol-1-yl)methyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
- CAS No.
- 1434288-24-0
- Chemical Name
- 2-((1H-benzo[d]imidazol-1-yl)methyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
- Synonyms
- PF-06284674;PF-06284674 >=98% (HPLC);4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(1H-benzimidazol-1-ylmethyl)-6-methyl-;2-((1H-benzo[d]imidazol-1-yl)methyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
- CBNumber
- CB74904376
- Molecular Formula
- C17H14N4O
- Formula Weight
- 290.32
- MOL File
- 1434288-24-0.mol
2-((1H-benzo[d]imidazol-1-yl)methyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Property
- storage temp.
- room temp
- solubility
- DMSO: 10mg/mL, clear
- form
- powder
- color
- white to brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
2-((1H-benzo[d]imidazol-1-yl)methyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Chemical Properties,Usage,Production
Uses
PF-06284674 (PKM2 activator 1) (Compound 8) is a PKM2 activator that can be used in cancer research[1].
Biological Activity
PF-06284674 is a cell permeable, potent and selective M2 isoform of pyruvate kinase (PKM2) activator.
References
[1] Guo C, et al. Discovery of 2-((1H-benzo [d] imidazol-1-yl) methyl)-4H-pyrido [1, 2-a] pyrimidin-4-ones as novel PKM2 activators[J]. Bioorganic & medicinal chemistry letters, 2013, 23(11): 3358-3363. DOI:10.1016/j.bmcl.2013.03.090
2-((1H-benzo[d]imidazol-1-yl)methyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Preparation Products And Raw materials
Raw materials
Preparation Products
2-((1H-benzo[d]imidazol-1-yl)methyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Suppliers
- Tel
- +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19962
- Advantage
- 58