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SODIUM 4-HYDROXYBUTYRATE

Product Name
SODIUM 4-HYDROXYBUTYRATE
CAS No.
502-85-2
Chemical Name
SODIUM 4-HYDROXYBUTYRATE
Synonyms
GHB;SODIUM OXYBATE;SODIUM 4-HYDROXYBUTANOATE;gammaoh;wy-3478;somsanit;NSC-84223;GHB SODIUM SALT;Levetiracetam-15;Oxybate (sodium)
CBNumber
CB7491645
Molecular Formula
C4H9NaO3
Formula Weight
128.1
MOL File
502-85-2.mol
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SODIUM 4-HYDROXYBUTYRATE Property

Melting point:
145-146°C
Flash point:
9℃
storage temp. 
Controlled Substance, -20°C Freezer
solubility 
DMSO (Slightly), Water (Slightly)
form 
solid
Merck 
13,4840
CAS DataBase Reference
502-85-2(CAS DataBase Reference)
EPA Substance Registry System
Butanoic acid, 4-hydroxy-, monosodium salt (502-85-2)
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
22-24/25-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
2
RTECS 
ET4750000
3
HazardClass 
IRRITANT
Toxicity
Highly sol in aq solns. LD50 in male, female rats (mg/kg): 2,000, 1,650 i.p. (Bruguerolle)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G-001
Product name
GHB sodium salt solution
Purity
1.0?mg/mL in methanol (as salt), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$31.1
Updated
2024/03/01
Cayman Chemical
Product number
9002506
Product name
GHB (sodium salt)
Purity
≥95%
Packaging
10mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
15661
Product name
GHB (sodium salt) (exempt preparation)
Purity
≥95%
Packaging
1mg
Price
$21
Updated
2024/03/01
Cayman Chemical
Product number
9002506
Product name
GHB (sodium salt)
Purity
≥95%
Packaging
50mg
Price
$70
Updated
2024/03/01
Atlantic Research Chemicals
Product number
CA10118
Product name
Sodium4-Hydroxybutanoate
Purity
95%
Packaging
10gm:
Price
$141.38
Updated
2021/12/16
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SODIUM 4-HYDROXYBUTYRATE Chemical Properties,Usage,Production

Description

Xyrem is distributed by Jazz Pharmaceuticals, Inc. (Palo Alto, CA). It is an oral solution of sodium oxybate prescribed for narcoleptic patients to treat extreme daytime sleepiness and cataplexy. Xyrem is also known as sodium oxybate which is the same as gamma hydroxybutyric acid (GHB), a drug of abuse. GHB is endogenously produced and present in the central nervous system (CNS) in small concentrations. Accidental overdosing has led to many hospitalizations and deaths. Because of the tendency to abuse GHB, it was classified as a schedule I controlled substance. This meant that GHB had a high potential for abuse and no medical purpose. However, in 2002, because of a series of clinical trials that demonstrated that the compound reduces cataplexy attacks, it was approved for use under the trademark Xyrem. Since GHB had previously been used as a ‘date-rape’ drug, Xyrem is considered a schedule III controlled substance and is distributed in accordance with strict FDA regulations. Xyrem may only be ordered through the ‘Xyrem Success Program.’ Illegal use is punishable under federal and state laws.

Description

GHB (sodium salt) (exempt preparation) (Item No. 15661) is an analytical reference standard categorized as a CNS depressant. GHB is a metabolite of γ-butyrolactone . It has a high potential for abuse. GHB is regulated as a Schedule I compound in the United States. GHB (sodium salt) (exempt preparation) (Item No. 15661) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.

Chemical Properties

white crystalline powder

Uses

antibacterial

Uses

4-Hydroxybutyric acid sodium salt is an agonist to both GHB and GABAB neural receptors, exhibiting neurotransmitter-like effects. It has been used as a general anesthetic in treatment for sleep disorders and clinical depression, but also has been identified as a “date rape drug”.

Uses

Xyrem is used as a prescription drug for the treatment of cataplexy in patients with narcolepsy. It can also be used illegally for recreational purposes as well as drug-facilitated sexual assault.

Indications

The substance is related to γ-aminobutyric acid, a cerebral metabolite that is supposed to be sleep inducing. When given i.p., it produces a shallow anesthesia (tolerance stage a: paralysis of the spinal cord and mesencephalon, slight relaxation of the muscles) that resembles natural sleep as seen via the electroencephalograph. It is employed as an anesthetic during labor and in combination anesthesia with nitrous oxide, barbiturates, or neuroleptanalgesics.

brand name

Xyrem (Jazz).

Environmental Fate

Xyrem is a water-soluble white to off-white powder, which can be disposed by dumping the oral solution down the sanitary sewer system. This is the preferred method of disposal for drugs which have a high potential for abuse and/or accidental overdose.

Toxicity evaluation

GHB is endogenously present in the brain and at low concentrations binds to GHB receptors that are excitatory. This effect can cause euphoria, making it a drug of abuse at ‘rave’ parties. However, at higher concentrations, Xyrem is a CNS depressant and this is the main mechanism of its toxicity. The negative effects are mediated by the gamma-aminobutyric acid (GABA)B receptors. The maximum stimulation of these receptors by GHB is w69% when compared to the binding of a GABAB receptor agonist. Therefore, the drug appears to be a weak agonist of the GABA-binding site of GABAB receptors. Overdose can lead to respiratory arrest and death. The combined use of other sedative hypnotic agents or alcohol can exacerbate the toxicity of Xyrem.

SODIUM 4-HYDROXYBUTYRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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SODIUM 4-HYDROXYBUTYRATE Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
Advantage
59
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
XinYao(Shenzhen) Biological Technology Co., Ltd.
Tel
0755-89880280
Fax
0755-89880280
Email
3004662104@qq.com
Country
China
ProdList
1829
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
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View Lastest Price from SODIUM 4-HYDROXYBUTYRATE manufacturers

Hebei Fengqiang Trading Co., LTD
Product
SODIUM 4-HYDROXYBUTYRATE 502-85-2
Price
US $100.00/bag
Min. Order
1bag
Purity
99
Supply Ability
5000
Release date
2023-09-01
Zhuozhou Wenxi import and Export Co., Ltd
Product
SODIUM 4-HYDROXYBUTYRATE 502-85-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
SODIUM 4-HYDROXYBUTYRATE 502-85-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

502-85-2, SODIUM 4-HYDROXYBUTYRATERelated Search:


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